4-[1-(acetylsulfanyl)-2-(Boc-amino)propyl]phenyl-(N-tert-butyl)sulfonamide

Base Information

Chemical Name:4-[1-(acetylsulfanyl)-2-(Boc-amino)propyl]phenyl-(N-tert-butyl)sulfonamide
CAS No.:623585-39-7
Molecular Formula:C₂₀H₃₂N₂O₅S₂
Molecular Weight:444.616
Hs Code.:

Synonyms:4-[1-(acetylsulfanyl)-2-(Boc-amino)propyl]phenyl-(N-tert-butyl)sulfonamide

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Chemical Property of 4-[1-(acetylsulfanyl)-2-(Boc-amino)propyl]phenyl-(N-tert-butyl)sulfonamide

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Technology Process of 4-[1-(acetylsulfanyl)-2-(Boc-amino)propyl]phenyl-(N-tert-butyl)sulfonamide

There total 2 articles about 4-[1-(acetylsulfanyl)-2-(Boc-amino)propyl]phenyl-(N-tert-butyl)sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 507-09-5
tiolacetic acid

: 623585-38-6
[2-(4-tert-butylsulfamoylphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester

: 623585-39-7
4-[1-(acetylsulfanyl)-2-(Boc-amino)propyl]phenyl-(N-tert-butyl)sulfonamide

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 72h;
DOI:10.1021/jm0300680

Reference yield:

: 2-tert-butoxycarbonylamino-3-(4-tert-butylsulfamoyl-phenyl)-propionic acid ethyl ester

: 623585-39-7
4-[1-(acetylsulfanyl)-2-(Boc-amino)propyl]phenyl-(N-tert-butyl)sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: isobutylchloroformate; N-methylmorpholine / 1,2-dimethoxy-ethane / 0.03 h / -15 °C

1.2: aq. NaBH₄ / 1,2-dimethoxy-ethane

2.1: 0.5 g / PPh₃; DEAD / tetrahydrofuran / 72 h / 20 °C

With 4-methyl-morpholine; triphenylphosphine; diethylazodicarboxylate; isobutyl chloroformate; In tetrahydrofuran; 1,2-dimethoxyethane; 2.1: Mitsunobu reaction;
DOI:10.1021/jm0300680