[2-(4-tert-butylsulfamoylphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester

Base Information

• Chemical Name: [2-(4-tert-butylsulfamoylphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester
• CAS No.: 623585-38-6
• Molecular Formula: C₁₈H₃₀N₂O₅S
• Molecular Weight: 386.513
• Mol file: 623585-38-6.mol

Synonyms:[2-(4-tert-butylsulfamoylphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester

Chemical Property of [2-(4-tert-butylsulfamoylphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of [2-(4-tert-butylsulfamoylphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester

There total 1 articles about [2-(4-tert-butylsulfamoylphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-tert-butoxycarbonylamino-3-(4-tert-butylsulfamoyl-phenyl)-propionic acid ethyl ester → [2-(4-tert-butylsulfamoylphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester (623585-38-6)

Guidance literature:

2-tert-butoxycarbonylamino-3-(4-tert-butylsulfamoyl-phenyl)-propionic acid ethyl ester; With 4-methyl-morpholine; isobutyl chloroformate; In 1,2-dimethoxyethane; at -15 ℃; for 0.0333333h;

With sodium tetrahydroborate; In 1,2-dimethoxyethane;

DOI:10.1021/jm0300680

Reference yield:

tiolacetic acid (507-09-5) + [2-(4-tert-butylsulfamoylphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester (623585-38-6) → 4-[1-(acetylsulfanyl)-2-(Boc-amino)propyl]phenyl-(N-tert-butyl)sulfonamide (623585-39-7)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 72h;

DOI:10.1021/jm0300680

Reference yield:

[2-(4-tert-butylsulfamoylphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester (623585-38-6) → 4-(2-amino-3-sulfanylpropyl)benzenesulfonic acid hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: 0.5 g / PPh₃; DEAD / tetrahydrofuran / 72 h / 20 °C

2: 40 percent / aq. HCl / 120 °C

With hydrogenchloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1: Mitsunobu reaction;

DOI:10.1021/jm0300680

Downstream raw materials:

4-[1-(acetylsulfanyl)-2-(Boc-amino)propyl]phenyl-(N-tert-butyl)sulfonamide