ethyl 2-(4-fluorophenyl)-2-((4-methylthio)benzoyl)acetic acid ethyl ester

Base Information

• Chemical Name: ethyl 2-(4-fluorophenyl)-2-((4-methylthio)benzoyl)acetic acid ethyl ester
• CAS No.: 329076-60-0
• Molecular Formula: C₁₈H₁₇FO₃S
• Molecular Weight: 332.396
• Mol file: 329076-60-0.mol

Synonyms:ethyl 2-(4-fluorophenyl)-2-((4-methylthio)benzoyl)acetic acid ethyl ester

Chemical Property of ethyl 2-(4-fluorophenyl)-2-((4-methylthio)benzoyl)acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl 2-(4-fluorophenyl)-2-((4-methylthio)benzoyl)acetic acid ethyl ester

There total 7 articles about ethyl 2-(4-fluorophenyl)-2-((4-methylthio)benzoyl)acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(4-fluorophenyl)-1-(4-(methylthio)phenyl)ethanone (87483-29-2) + ethyl cyanoformate (623-49-4) → ethyl 2-(4-fluorophenyl)-2-((4-methylthio)benzoyl)acetic acid ethyl ester (329076-60-0)

Guidance literature:

2-(4-fluorophenyl)-1-(4-(methylthio)phenyl)ethanone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

ethyl cyanoformate; In tetrahydrofuran; at -78 - 20 ℃; for 6h;

DOI:10.1021/jo049264k

Reference yield: 69.0%

4-(methylthio)benzoyl chloride (1442-06-4) + ethyl 2-(4-fluorophenyl)acetate (587-88-2) → ethyl 2-(4-fluorophenyl)-2-((4-methylthio)benzoyl)acetic acid ethyl ester (329076-60-0)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1021/jo049264k

Reference yield:

p-cyanophenyl methyl sulfide (21382-98-9) → ethyl 2-(4-fluorophenyl)-2-((4-methylthio)benzoyl)acetic acid ethyl ester (329076-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Mg / diethyl ether / 2 h / Heating

1.2: 22 percent / diethyl ether / 14 h / 20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: 83 percent / tetrahydrofuran / 6 h / -78 - 20 °C

With magnesium; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo049264k

upstream raw materials:

2-(4-fluorophenyl)-1-(4-(methylthio)phenyl)ethanone

ethyl cyanoformate

4-(methylthio)benzoyl chloride

ethyl 2-(4-fluorophenyl)acetate

Downstream raw materials:

4-(4-Fluorophenyl)-5-(4-(methylthio)phenyl)-1H-pyrazol-3-ol

4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-3-hydroxypyrazole

3-Ethyl-7-(4-fluorophenyl)-6-(4-(methylsulphonyl)phenyl)pyrazolo[5,1-b][1,3]oxazole

1-[(4-(4-Fluorophenyl)-5-(4-(methylsulphonyl)phenyl)-1H-pyrazol-3-yl)oxy]-3,3-dimethylbutan-2-one