3-(4-fluorophenacyloxy)-4-(4-fluorophenyl)-5-(4-methanesulfonylphenyl)pyrazole

Base Information

Chemical Name:3-(4-fluorophenacyloxy)-4-(4-fluorophenyl)-5-(4-methanesulfonylphenyl)pyrazole
CAS No.:329076-08-6
Molecular Formula:C₂₄H₁₈F₂N₂O₄S
Molecular Weight:468.481
Hs Code.:

Synonyms:3-(4-fluorophenacyloxy)-4-(4-fluorophenyl)-5-(4-methanesulfonylphenyl)pyrazole

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Chemical Property of 3-(4-fluorophenacyloxy)-4-(4-fluorophenyl)-5-(4-methanesulfonylphenyl)pyrazole

Chemical Property:

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Technology Process of 3-(4-fluorophenacyloxy)-4-(4-fluorophenyl)-5-(4-methanesulfonylphenyl)pyrazole

There total 12 articles about 3-(4-fluorophenacyloxy)-4-(4-fluorophenyl)-5-(4-methanesulfonylphenyl)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 329076-65-5
4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-3-hydroxypyrazole

: 329076-08-6
3-(4-fluorophenacyloxy)-4-(4-fluorophenyl)-5-(4-methanesulfonylphenyl)pyrazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 0.833333h;
DOI:10.1021/jo049264k

Reference yield:

: 587-88-2
ethyl 2-(4-fluorophenyl)acetate

: 329076-08-6
3-(4-fluorophenacyloxy)-4-(4-fluorophenyl)-5-(4-methanesulfonylphenyl)pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

2: 95 percent / hydrazine hydrate; AcOH / dioxane; H₂O / 24 h / Heating

3: 90 percent / peracetic acid / CH₂Cl₂ / 4 h / 0 °C

4: 99 percent / K₂CO₃ / dimethylformamide / 0.83 h / 50 °C

With peracetic acid; potassium carbonate; hydrazine hydrate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo049264k

Reference yield:

: 405-50-5
p-Fluorophenylacetic acid

: 329076-08-6
3-(4-fluorophenacyloxy)-4-(4-fluorophenyl)-5-(4-methanesulfonylphenyl)pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / H₂SO₄ / 8 h / Heating

2: 69 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

3: 95 percent / hydrazine hydrate; AcOH / dioxane; H₂O / 24 h / Heating

4: 90 percent / peracetic acid / CH₂Cl₂ / 4 h / 0 °C

5: 99 percent / K₂CO₃ / dimethylformamide / 0.83 h / 50 °C

With peracetic acid; sulfuric acid; potassium carbonate; hydrazine hydrate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo049264k