N-(tert-butyloxycarbonyl)-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

Base Information

Chemical Name:N-(tert-butyloxycarbonyl)-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester
CAS No.:84850-92-0
Molecular Formula:C₃₁H₅₀N₄O₈
Molecular Weight:606.76
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

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Chemical Property of N-(tert-butyloxycarbonyl)-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

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Technology Process of N-(tert-butyloxycarbonyl)-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

There total 1 articles about N-(tert-butyloxycarbonyl)-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 33294-55-2
(S)-2-(tert-butoxycarbonylamino)-3-methylbutanoic anhydride

: 84851-31-0
(S,S)-Sta-Ala-Phe-OMe hydrochloride

: 84850-92-0
N-(tert-butyloxycarbonyl)-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

Guidance literature:: With 4-methyl-morpholine; In dichloromethane;
DOI:10.1021/jm00360a022

Reference yield:

: 84850-92-0
N-(tert-butyloxycarbonyl)-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

: 84851-32-1
Val-(S,S)-Sta-Ala-Phe-OMe hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 1h; Ambient temperature;
DOI:10.1021/jm00398a022

Reference yield:

: 84850-92-0
N-(tert-butyloxycarbonyl)-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

: 112151-88-9
N-(tert-butyloxycarbonyl)-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / dioxane / 1 h / Ambient temperature

2: 78 percent / N-hydroxybenzotriazole, diisopropylethylamine, dicyclohexylcarbodiimide / dimethylformamide; CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature

With hydrogenchloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00398a022