2-amino-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester hydrochloride

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Chemical Name:2-amino-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester hydrochloride
CAS No.:112151-84-5
Molecular Formula:C₃₇H₅₄N₆O₈*ClH
Molecular Weight:747.332
Hs Code.:

Synonyms:2-amino-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester hydrochloride

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Chemical Property of 2-amino-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester hydrochloride

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Technology Process of 2-amino-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester hydrochloride

There total 5 articles about 2-amino-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 112151-88-9
N-(tert-butyloxycarbonyl)-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

: 112151-84-5
2-amino-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at -20 ℃; for 1h;
DOI:10.1021/jm00398a022

Reference yield:

: 42280-29-5
[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoylamino]acetic acid benzyl ester

: 112151-84-5
2-amino-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium on carbon

2: 78 percent / N-hydroxybenzotriazole, diisopropylethylamine, dicyclohexylcarbodiimide / dimethylformamide; CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature

3: 95 percent / HCl / ethyl acetate / 1 h / -20 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00398a022

Reference yield:

: 25616-33-5
2-((2S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)acetic acid

: 112151-84-5
2-amino-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / N-hydroxybenzotriazole, diisopropylethylamine, dicyclohexylcarbodiimide / dimethylformamide; CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature

2: 95 percent / HCl / ethyl acetate / 1 h / -20 °C

With hydrogenchloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00398a022