N-(tert-butyloxycarbonyl)-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

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Chemical Name:N-(tert-butyloxycarbonyl)-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester
CAS No.:112151-88-9
Molecular Formula:C₄₂H₆₂N₆O₁₀
Molecular Weight:810.988
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

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Chemical Property of N-(tert-butyloxycarbonyl)-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

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Technology Process of N-(tert-butyloxycarbonyl)-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

There total 3 articles about N-(tert-butyloxycarbonyl)-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 25616-33-5
2-((2S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)acetic acid

: 84851-32-1
Val-(S,S)-Sta-Ala-Phe-OMe hydrochloride

: 112151-88-9
N-(tert-butyloxycarbonyl)-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; 1.) 0 deg C, 3 h, 2.) room temperature;
DOI:10.1021/jm00398a022

Reference yield:

: 42280-29-5
[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoylamino]acetic acid benzyl ester

: 112151-88-9
N-(tert-butyloxycarbonyl)-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium on carbon

2: 78 percent / N-hydroxybenzotriazole, diisopropylethylamine, dicyclohexylcarbodiimide / dimethylformamide; CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00398a022

Reference yield:

: 84850-92-0
N-(tert-butyloxycarbonyl)-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

: 112151-88-9
N-(tert-butyloxycarbonyl)-L-phenylalanylglycyl-L-valyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / dioxane / 1 h / Ambient temperature

2: 78 percent / N-hydroxybenzotriazole, diisopropylethylamine, dicyclohexylcarbodiimide / dimethylformamide; CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature

With hydrogenchloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00398a022