4-cyano-3-(2,4-dichlorophenyl)-N-methoxy-N-methyl-5-morpholinothiophene-2-carboxamide

Base Information

Chemical Name:4-cyano-3-(2,4-dichlorophenyl)-N-methoxy-N-methyl-5-morpholinothiophene-2-carboxamide
CAS No.:1202041-95-9
Molecular Formula:C₁₈H₁₇Cl₂N₃O₃S
Molecular Weight:426.323
Hs Code.:

Synonyms:4-cyano-3-(2,4-dichlorophenyl)-N-methoxy-N-methyl-5-morpholinothiophene-2-carboxamide

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Chemical Property of 4-cyano-3-(2,4-dichlorophenyl)-N-methoxy-N-methyl-5-morpholinothiophene-2-carboxamide

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Technology Process of 4-cyano-3-(2,4-dichlorophenyl)-N-methoxy-N-methyl-5-morpholinothiophene-2-carboxamide

There total 6 articles about 4-cyano-3-(2,4-dichlorophenyl)-N-methoxy-N-methyl-5-morpholinothiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202041-94-8
4-cyano-3-(2,4-dichlorophenyl)-5-morpholin-4-ylthiophene-2-carboxylic acid chloride

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1202041-95-9
4-cyano-3-(2,4-dichlorophenyl)-N-methoxy-N-methyl-5-morpholinothiophene-2-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 15029-32-0
4-cyanoacetylmorpholine

: 1202041-95-9
4-cyano-3-(2,4-dichlorophenyl)-N-methoxy-N-methyl-5-morpholinothiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: Lawessons reagent / tetrahydrofuran / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 0 - 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h / 140 °C / Microwave irradiation; Inert atmosphere

4: water; sodium hydroxide / tetrahydrofuran; methanol / 20 h / 20 °C

5: thionyl chloride / toluene / 1 h / 80 °C

6: triethylamine / dichloromethane / 1 h / 0 °C

With Lawessons reagent; thionyl chloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1174304-59-6
C₁₄H₁₂Cl₂N₂O₂S

: 1202041-95-9
4-cyano-3-(2,4-dichlorophenyl)-N-methoxy-N-methyl-5-morpholinothiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h / 140 °C / Microwave irradiation; Inert atmosphere

2: water; sodium hydroxide / tetrahydrofuran; methanol / 20 h / 20 °C

3: thionyl chloride / toluene / 1 h / 80 °C

4: triethylamine / dichloromethane / 1 h / 0 °C

With thionyl chloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;