N-(3-fluoro-4-(7-methoxyquinoline-4-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

Base Information

Chemical Name:N-(3-fluoro-4-(7-methoxyquinoline-4-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide
CAS No.:1415798-14-9
Molecular Formula:C₂₉H₁₈F₂N₄O₄S
Molecular Weight:556.549
Hs Code.:

Synonyms:N-(3-fluoro-4-(7-methoxyquinoline-4-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

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Chemical Property of N-(3-fluoro-4-(7-methoxyquinoline-4-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

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Technology Process of N-(3-fluoro-4-(7-methoxyquinoline-4-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

There total 8 articles about N-(3-fluoro-4-(7-methoxyquinoline-4-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 913376-57-5
3-fluoro-4-(7-methoxyquinolin-4-yloxy)benzenamine

: 1415797-75-9
4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formic acid

: 1415798-14-9
N-(3-fluoro-4-(7-methoxyquinoline-4-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

: 1415797-72-6
ethyl 5-(N-(4-fluorophenyl)-2-methoxycarbonylacetamido)thiazole-4-formate

: 1415798-14-9
N-(3-fluoro-4-(7-methoxyquinoline-4-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium methylate / methanol / 20 °C

2: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; triethylsilane; triethylamine / 3 h / 80 °C

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 0.5 h / 20 °C

5: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With triethylsilane; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide monohydrate; sodium methylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1415797-74-8
methyl 4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formate

: 1415798-14-9
N-(3-fluoro-4-(7-methoxyquinoline-4-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 0.5 h / 20 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;