2-[1-(3,3-Diethoxy-propyl)-2-(4-fluoro-phenyl)-5-isopropyl-1H-pyrrol-3-yl]-pyridine

Base Information

Chemical Name:2-[1-(3,3-Diethoxy-propyl)-2-(4-fluoro-phenyl)-5-isopropyl-1H-pyrrol-3-yl]-pyridine
CAS No.:135833-92-0
Molecular Formula:C₂₅H₃₁FN₂O₂
Molecular Weight:410.532
Hs Code.:

Synonyms:2-[1-(3,3-Diethoxy-propyl)-2-(4-fluoro-phenyl)-5-isopropyl-1H-pyrrol-3-yl]-pyridine

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Chemical Property of 2-[1-(3,3-Diethoxy-propyl)-2-(4-fluoro-phenyl)-5-isopropyl-1H-pyrrol-3-yl]-pyridine

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Technology Process of 2-[1-(3,3-Diethoxy-propyl)-2-(4-fluoro-phenyl)-5-isopropyl-1H-pyrrol-3-yl]-pyridine

There total 3 articles about 2-[1-(3,3-Diethoxy-propyl)-2-(4-fluoro-phenyl)-5-isopropyl-1H-pyrrol-3-yl]-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 41365-75-7
aminopropane diethyl acetal

: 115672-63-4
1-(4-fluorophenyl)-5-methyl-2-(2-pyridyl)-1,4-hexanedione

: 135833-92-0
2-[1-(3,3-Diethoxy-propyl)-2-(4-fluoro-phenyl)-5-isopropyl-1H-pyrrol-3-yl]-pyridine

Guidance literature:: With water; toluene-4-sulfonic acid; In toluene; for 24h; Heating;
DOI:10.1021/jm00105a056

Reference yield:

: 1121-60-4
pyridine-2-carbaldehyde

: 135833-92-0
2-[1-(3,3-Diethoxy-propyl)-2-(4-fluoro-phenyl)-5-isopropyl-1H-pyrrol-3-yl]-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine, HOAc / toluene / 3 h / Heating

2: 1.) Et₃N, 2-(2-hydroxyethyl)-3-methyl-4-benzylthiazolium chloride, 2.) NaOH / 1.) 70 deg C, 24 h, 2.) THF, water

3: 76 percent / p-TSA, H₂O / toluene / 24 h / Heating

With piperidine; sodium hydroxide; 2-(2-hydroxyethyl)-3-methyl-4-benzylthiazolium chloride; water; toluene-4-sulfonic acid; acetic acid; triethylamine; In toluene;
DOI:10.1021/jm00105a056

Reference yield:

: 42558-54-3
Methyl 4-methyl-3-oxopentanoate

: 135833-92-0
2-[1-(3,3-Diethoxy-propyl)-2-(4-fluoro-phenyl)-5-isopropyl-1H-pyrrol-3-yl]-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine, HOAc / toluene / 3 h / Heating

2: 1.) Et₃N, 2-(2-hydroxyethyl)-3-methyl-4-benzylthiazolium chloride, 2.) NaOH / 1.) 70 deg C, 24 h, 2.) THF, water

3: 76 percent / p-TSA, H₂O / toluene / 24 h / Heating

With piperidine; sodium hydroxide; 2-(2-hydroxyethyl)-3-methyl-4-benzylthiazolium chloride; water; toluene-4-sulfonic acid; acetic acid; triethylamine; In toluene;
DOI:10.1021/jm00105a056