4-(3,5-di-tert-butyl-4-hydroxyphenyl)-N,2-dimethylpyrimidine-5-carboxamide

Base Information

Chemical Name:4-(3,5-di-tert-butyl-4-hydroxyphenyl)-N,2-dimethylpyrimidine-5-carboxamide
CAS No.:1361383-65-4
Molecular Formula:C₂₁H₂₉N₃O₂
Molecular Weight:355.48
Hs Code.:

Synonyms:4-(3,5-di-tert-butyl-4-hydroxyphenyl)-N,2-dimethylpyrimidine-5-carboxamide

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Chemical Property of 4-(3,5-di-tert-butyl-4-hydroxyphenyl)-N,2-dimethylpyrimidine-5-carboxamide

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Technology Process of 4-(3,5-di-tert-butyl-4-hydroxyphenyl)-N,2-dimethylpyrimidine-5-carboxamide

There total 5 articles about 4-(3,5-di-tert-butyl-4-hydroxyphenyl)-N,2-dimethylpyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1361383-62-1
2-(3,5-di-tert-butyl-4-hydroxybenzoyl)-3-dimethylamino-N-methylprop-2-enamide

: 124-42-5
acetamidine hydrochloride

: 1361383-65-4
4-(3,5-di-tert-butyl-4-hydroxyphenyl)-N,2-dimethylpyrimidine-5-carboxamide

Guidance literature:: With potassium tert-butylate; In isopropyl alcohol; at 74 - 80 ℃; for 2.16667h;

Reference yield: 70.0%

: 1361383-61-0
3-(3,5-di-tert-butyl-4-hydroxyphenyl)-N-methyl-3-oxopropanamide

: 124-42-5
acetamidine hydrochloride

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1361383-65-4
4-(3,5-di-tert-butyl-4-hydroxyphenyl)-N,2-dimethylpyrimidine-5-carboxamide

Guidance literature:: 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-N-methyl-3-oxopropanamide; N,N-dimethyl-formamide dimethyl acetal; In toluene; at 20 ℃; for 2h;

acetamidine hydrochloride; With potassium tert-butylate; In toluene; at 20 - 80 ℃;

Reference yield:

: 14035-33-7
1-(3,5-di-tert-butyl-4-hydroxyphenyl)ethanone

: 1361383-65-4
4-(3,5-di-tert-butyl-4-hydroxyphenyl)-N,2-dimethylpyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -60 - -50 °C

1.2: -20 - -5 °C / Cooling with ice

2.1: water / 2 h

3.1: toluene / 2 h / 20 °C

3.2: 20 - 80 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; water; toluene;