1-(2-(4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy) methyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

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Chemical Name:1-(2-(4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy) methyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one
CAS No.:1413912-59-0
Molecular Formula:C₂₄H₃₄N₄O₃Si
Molecular Weight:454.644
Hs Code.:

Synonyms:1-(2-(4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy) methyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

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Chemical Property of 1-(2-(4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy) methyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

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Technology Process of 1-(2-(4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy) methyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

There total 4 articles about 1-(2-(4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy) methyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1184852-50-3
1-(2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-yl)-2,2-dimethylpropane-1-one

: 623-04-1
4-aminobenzenemethanol

: 1413912-59-0
1-(2-(4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy) methyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

Guidance literature:: 1-(2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-yl)-2,2-dimethylpropane-1-one; 4-aminobenzenemethanol; With caesium carbonate; In toluene; at 20 ℃; for 0.75h; Sealed tube; Inert atmosphere;

With Ru(OCOCH₃)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; palladium diacetate; at 110 ℃; for 4h;

Reference yield:

: 875781-41-2
5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

: 1413912-59-0
1-(2-(4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy) methyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1.83 h / 20 - 65 °C / Inert atmosphere

2.1: diethyl aluminiumcholoride / dichloromethane; hexane / 0.5 h / 0 °C / Inert atmosphere

2.2: 21.17 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.42 h / 0 °C

3.2: 0.5 h / 0 - 20 °C

4.1: caesium carbonate / toluene / 0.75 h / 20 °C / Sealed tube; Inert atmosphere

4.2: 4 h / 110 °C

With diethyl aluminiumcholoride; potassium tert-butylate; sodium hydride; caesium carbonate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; paraffin oil;

Reference yield:

: 875781-43-4
2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1413912-59-0
1-(2-(4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy) methyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethyl aluminiumcholoride / dichloromethane; hexane / 0.5 h / 0 °C / Inert atmosphere

1.2: 21.17 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.42 h / 0 °C

2.2: 0.5 h / 0 - 20 °C

3.1: caesium carbonate / toluene / 0.75 h / 20 °C / Sealed tube; Inert atmosphere

3.2: 4 h / 110 °C

With diethyl aluminiumcholoride; sodium hydride; caesium carbonate; In hexane; dichloromethane; N,N-dimethyl-formamide; toluene; paraffin oil;