[2S-(2α(1S,2R),3aα,4β,7β,7aα)]-2-[2-(2-methoxy-2,2-diphenylethoxy)-1,2-diphenylethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Base Information

Chemical Name:[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(2-methoxy-2,2-diphenylethoxy)-1,2-diphenylethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran
CAS No.:870298-18-3
Molecular Formula:C₄₁H₄₆O₄
Molecular Weight:602.814
Hs Code.:

Synonyms:[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(2-methoxy-2,2-diphenylethoxy)-1,2-diphenylethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

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Chemical Property of [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(2-methoxy-2,2-diphenylethoxy)-1,2-diphenylethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

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Technology Process of [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(2-methoxy-2,2-diphenylethoxy)-1,2-diphenylethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

There total 3 articles about [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(2-methoxy-2,2-diphenylethoxy)-1,2-diphenylethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 870298-16-1
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-1,1-diphenylethanol

: 74-88-4
methyl iodide

: 870298-18-3
[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(2-methoxy-2,2-diphenylethoxy)-1,2-diphenylethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Guidance literature:: With 18-crown-6 ether; sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.tetasy.2005.08.030

Reference yield:

: 824952-29-6
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethanol

: 870298-18-3
[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(2-methoxy-2,2-diphenylethoxy)-1,2-diphenylethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / sodium hydride / tetrahydrofuran; hexamethylphosphoric acid triamide / Heating

2: 74 percent / tetrahydrofuran / 24 h / Heating

3: 91 percent / sodium hydride; 18-crown-6 / dimethylformamide / 20 °C

With 18-crown-6 ether; sodium hydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2005.08.030

Reference yield:

: 866456-89-5
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]acetic acid 1,1-dimethylethyl ester

: 870298-18-3
[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(2-methoxy-2,2-diphenylethoxy)-1,2-diphenylethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / tetrahydrofuran / 24 h / Heating

2: 91 percent / sodium hydride; 18-crown-6 / dimethylformamide / 20 °C

With 18-crown-6 ether; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2005.08.030