(R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid, dicyclohexylamine salt

Base Information

• Chemical Name: (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid, dicyclohexylamine salt
• CAS No.: 1265819-90-6
• Molecular Formula: C₁₂H₂₃N*C₁₅H₁₉ClO₄S
• Molecular Weight: 512.154
• Mol file: 1265819-90-6.mol

Synonyms:(R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid, dicyclohexylamine salt

Chemical Property of (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid, dicyclohexylamine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid, dicyclohexylamine salt

There total 8 articles about (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid, dicyclohexylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt (1265819-85-9) → (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid, dicyclohexylamine salt (1265819-90-6)

Guidance literature:

With hydrogen; [Ir(COD)2]BF₄; (2S,4S)-2,4-bis[di(3,5-dimethylphenyl)phosphino]pentane; In dichloromethane; at 20 - 50 ℃; for 20h; under 37503.8 Torr; Product distribution / selectivity; Autoclave;

Reference yield: 100.0%

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid, dicyclohexylamine salt → (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid, dicyclohexylamine salt (1265819-90-6)

Guidance literature:

With hydrogen; bis(1,5-cyclooctadiene)iridium(I) tetrafluoroborate; (2S,4S)-2,4-bis[di(3,5-dimethylphenyl)phosphino]pentane; In methanol; at 50 ℃; for 18h; under 37503.8 Torr; Product distribution / selectivity; Autoclave;

Reference yield:

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid, dicyclohexylamine salt → (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid, dicyclohexylamine salt (1265819-90-6) + (S)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid, dicyclohexylamine salt (1265819-93-9)

Guidance literature:

With hydrogen; Ru(OAc)2((R)-DiMeOBIPHEP); In methanol; at 50 ℃; under 37503.8 Torr; Product distribution / selectivity; Autoclave;

upstream raw materials:

(3-chloro-4-methylsulfanyl-phenyl)-acetic acid

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid

(3-Chloro-4-methanesulfonyl-phenyl)acetic acid

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt

Downstream raw materials:

(R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid