(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt

Base Information

• Chemical Name: (E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt
• CAS No.: 1265819-85-9
• Molecular Formula: C₁₂H₂₃N*C₁₅H₁₇ClO₄S
• Molecular Weight: 510.138
• Mol file: 1265819-85-9.mol

Synonyms:(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt

Chemical Property of (E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt

There total 3 articles about (E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid (345635-33-8) + N-cyclohexyl-cyclohexanamine (101-83-7) → (E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt (1265819-85-9)

Guidance literature:

In acetone; at 0 - 20 ℃; for 22h;

Reference yield:

(3-chloro-4-methylsulfanyl-phenyl)-acetic acid (87776-75-8) → (E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt (1265819-85-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dihydrogen peroxide / water; formic acid / 22 h / 50 °C

2.1: acetic anhydride; sodium acetate / tetrahydrofuran / 24 h / 40 °C

2.2: 2 h / 40 °C

2.3: pH 6 / Cooling with ice

3.1: acetone / 22 h / 0 - 20 °C

With dihydrogen peroxide; sodium acetate; acetic anhydride; In tetrahydrofuran; formic acid; water; acetone;

Reference yield:

(3-Chloro-4-methanesulfonyl-phenyl)acetic acid (1265819-83-7) → (E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt (1265819-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic anhydride; sodium acetate / tetrahydrofuran / 24 h / 40 °C

1.2: 2 h / 40 °C

1.3: pH 6 / Cooling with ice

2.1: acetone / 22 h / 0 - 20 °C

With sodium acetate; acetic anhydride; In tetrahydrofuran; acetone;

upstream raw materials:

(3-chloro-4-methylsulfanyl-phenyl)-acetic acid

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid

N-cyclohexyl-cyclohexanamine

(3-Chloro-4-methanesulfonyl-phenyl)acetic acid

Downstream raw materials:

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid

(R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid

(E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt

(R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid, dicyclohexylamine salt