Chemical Property of Lomustine
Chemical Property:
- Appearance/Colour:Yellow powder
- Vapor Pressure:0.00142mmHg at 25°C
- Melting Point:88-90 °C
- Refractive Index:1.57
- Boiling Point:296.6°C at 760 mmHg
- PKA:10.88±0.20(Predicted)
- Flash Point:133.2°C
- PSA：61.77000
- Density:1.35 g/cm3
- LogP:2.64180
- Storage Temp.:−20°C
- Solubility.:Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent).
- XLogP3:2.8
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:3
- Exact Mass:233.0931045
- Heavy Atom Count:15
- Complexity:219
- Purity/Quality:
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98.5%, *data from raw suppliers
Lomustine *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
45-25
- Safety Statements:
53-45
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Drug Classes:Antineoplastic Agents, Alkylating Agents
- Canonical SMILES:C1CCC(CC1)NC(=O)N(CCCl)N=O
- Recent ClinicalTrials:9-ING-41 in Patients With Advanced Cancers
- Recent EU Clinical Trials:A Multicenter, Open-Label Study with a Randomized Control Arm of the Efficacy, Safety, and Pharmacokinetics of Intravenously Infused Berubicin in Adult Patients with Recurrent Glioblastoma Multiforme (WHO Grade IV) After Failure of Standard First Line Therapy
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Uses
CCNU is an oral anticancer drug that was approved by the U.S. Food and Drug Administration in 1976 for marketing, as lomustine (FDA 2009a). CCNU is used alone or in combination with other antineoplastic agents, including procarbazine and vincristine, etoposide and prednimustine, and other combinations (IARC 1981, HSDB 2009). It is used primarily in the treatment of Hodgkin’s disease and brain tumors, but it has also been used to treat other cancer, includ-ing lung cancer, non-Hodgkin’s lymphoma, malignant melanoma, breast cancer, kidney cancer, and cancer of the gastrointestinal tract (MedlinePlus 2009). It has also been applied to the skin to treat mycosis fungoides and psoriasis. Lomustine USP is used to treat Malignant brain tumors; Hodgkin’s disease. Chloroethylnitrosourea derivative with antitumor activity. Similar to carmustine, chlorozotocin, nimustine, ranimustine. Antineoplastic.
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Clinical Use
#N/A
