4-((2-amino-6-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)sulfanyl)benzoic acid methyl ester

Base Information

Chemical Name:4-((2-amino-6-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)sulfanyl)benzoic acid methyl ester
CAS No.:147150-00-3
Molecular Formula:C₁₇H₁₅N₃O₃S
Molecular Weight:341.39
Hs Code.:

Synonyms:4-((2-amino-6-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)sulfanyl)benzoic acid methyl ester

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Chemical Property of 4-((2-amino-6-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)sulfanyl)benzoic acid methyl ester

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Technology Process of 4-((2-amino-6-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)sulfanyl)benzoic acid methyl ester

There total 7 articles about 4-((2-amino-6-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)sulfanyl)benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7745-91-7
3-bromo-4-methylaniline

: 147150-00-3
4-((2-amino-6-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)sulfanyl)benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 76 percent / sodium sulfate, conc. HCl, hydroxylamine hydrochloride / H₂O / 1 h / 100 °C

2: 50.7 percent / conc. H₂SO₄ / 1 h / 80 °C

3: 98 percent / 3 N aq. NaOH, 30percent H₂O₂ / 1 h / 80 °C

4: tetrahydrofuran / 12 h

5: Heating

6: 88 percent / bis-(2-methoxy-ethyl) ether / 1 h / Heating

7: 1.) NaH, 2.) CuBr, Cu₂O / 1.) DMA, RT, 1 h, 2.) DMA, 90 deg C, 4 h

With copper(I) oxide; hydrogenchloride; sodium hydroxide; sulfuric acid; hydroxylamine hydrochloride; dihydrogen peroxide; sodium hydride; sodium sulfate; copper(I) bromide; In tetrahydrofuran; diethylene glycol dimethyl ether; water;
DOI:10.1021/jm00058a010

Reference yield:

: 147149-84-6
4-bromo-5-methyl-1H-indole-2,3-dione

: 147150-00-3
4-((2-amino-6-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)sulfanyl)benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / 3 N aq. NaOH, 30percent H₂O₂ / 1 h / 80 °C

2: tetrahydrofuran / 12 h

3: Heating

4: 88 percent / bis-(2-methoxy-ethyl) ether / 1 h / Heating

5: 1.) NaH, 2.) CuBr, Cu₂O / 1.) DMA, RT, 1 h, 2.) DMA, 90 deg C, 4 h

With copper(I) oxide; sodium hydroxide; dihydrogen peroxide; sodium hydride; copper(I) bromide; In tetrahydrofuran; diethylene glycol dimethyl ether;
DOI:10.1021/jm00058a010

Reference yield:

: 147149-88-0
methyl 2-amino-6-bromo-5-methylbenzoate

: 147150-00-3
4-((2-amino-6-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)sulfanyl)benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / bis-(2-methoxy-ethyl) ether / 1 h / Heating

2: 1.) NaH, 2.) CuBr, Cu₂O / 1.) DMA, RT, 1 h, 2.) DMA, 90 deg C, 4 h

With copper(I) oxide; sodium hydride; copper(I) bromide; In diethylene glycol dimethyl ether;
DOI:10.1021/jm00058a010