(3S,4S)-3-benzylamino-3-methyl-1-pentyne-4,5-diol 5-t-butyldimethylsilyl ether

Base Information

Chemical Name:(3S,4S)-3-benzylamino-3-methyl-1-pentyne-4,5-diol 5-t-butyldimethylsilyl ether
CAS No.:195203-90-8
Molecular Formula:C₁₉H₃₁NO₂Si
Molecular Weight:333.546
Hs Code.:

Synonyms:(3S,4S)-3-benzylamino-3-methyl-1-pentyne-4,5-diol 5-t-butyldimethylsilyl ether

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4S)-3-benzylamino-3-methyl-1-pentyne-4,5-diol 5-t-butyldimethylsilyl ether

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Technology Process of (3S,4S)-3-benzylamino-3-methyl-1-pentyne-4,5-diol 5-t-butyldimethylsilyl ether

There total 3 articles about (3S,4S)-3-benzylamino-3-methyl-1-pentyne-4,5-diol 5-t-butyldimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 195203-89-5
(3S,4S)-3-benzylamino-3-methyl-1-pentyne-4,5-diol

: 195203-90-8
(3S,4S)-3-benzylamino-3-methyl-1-pentyne-4,5-diol 5-t-butyldimethylsilyl ether

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; 1.) 0 deg C, 2 h, 2.) 20 deg C, 8 h;
DOI:10.1016/S0040-4020(97)00366-9

Reference yield:

: 6153-06-6,105-29-3
(E)-3-methylpent-2-en-4-yn-1-ol

: 195203-90-8
(3S,4S)-3-benzylamino-3-methyl-1-pentyne-4,5-diol 5-t-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Ti(O-i-Pr)4, D-(-)-diisopropyl tartrate, cumene hydroperoxide, molecular sieves, 2.) Ti(O-i-Pr)4 / 1.) CH₂Cl₂, -25 deg C, 3 h, 2.) 20 deg C, 2 h

2: 90 percent / imidazole / dimethylformamide / 1.) 0 deg C, 2 h, 2.) 20 deg C, 8 h

With 1H-imidazole; titanium(IV) isopropylate; molecular sieve; Cumene hydroperoxide; D-(-)-diisopropyl tartrate; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)00366-9

Reference yield:

: 100-46-9
benzylamine

: 195203-90-8
(3S,4S)-3-benzylamino-3-methyl-1-pentyne-4,5-diol 5-t-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Ti(O-i-Pr)4, D-(-)-diisopropyl tartrate, cumene hydroperoxide, molecular sieves, 2.) Ti(O-i-Pr)4 / 1.) CH₂Cl₂, -25 deg C, 3 h, 2.) 20 deg C, 2 h

2: 90 percent / imidazole / dimethylformamide / 1.) 0 deg C, 2 h, 2.) 20 deg C, 8 h

With 1H-imidazole; titanium(IV) isopropylate; molecular sieve; Cumene hydroperoxide; D-(-)-diisopropyl tartrate; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)00366-9