α-cyclopropyl-2-methoxystyrene

Base Information

• Chemical Name: α-cyclopropyl-2-methoxystyrene
• CAS No.: 1355988-71-4
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.243
• Mol file: 1355988-71-4.mol

Synonyms:α-cyclopropyl-2-methoxystyrene

Chemical Property of α-cyclopropyl-2-methoxystyrene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-cyclopropyl-2-methoxystyrene

There total 1 articles about α-cyclopropyl-2-methoxystyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cyclopropyl(2-methoxyphenyl)methanone (400614-05-3) + Methyltriphenylphosphonium bromide (1779-49-3) → α-cyclopropyl-2-methoxystyrene (1355988-71-4)

Guidance literature:

Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 1h; Inert atmosphere;

cyclopropyl(2-methoxyphenyl)methanone; In tetrahydrofuran; hexane; at 40 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.joc.6b01825

Reference yield: 77.0%

diiron nonacarbonyl (15321-51-4) + α-cyclopropyl-2-methoxystyrene (1355988-71-4) → 2'-methoxy-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one (58713-52-3)

Guidance literature:

diiron nonacarbonyl; α-cyclopropyl-2-methoxystyrene; In tert-butyl alcohol; at 90 ℃; for 12h; Inert atmosphere; Sealed tube;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2016.01.046

Reference yield: 77.0%

α-cyclopropyl-2-methoxystyrene (1355988-71-4) + sodium 4-methylbenzenesulfinate (824-79-3) → 5-methoxy-4-(tosylmethyl)-1,2-dihydronaphthalene

Guidance literature:

With dipotassium peroxodisulfate; silver nitrate; In toluene; at 90 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1039/d0ob01570a

upstream raw materials:

cyclopropyl(2-methoxyphenyl)methanone

Methyltriphenylphosphonium bromide

Downstream raw materials:

C₁₃H₁₄O₂

2'-methoxy-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one

Refernces

• 1、 Jiang, Guo-Jie,Fu, Xu-Fei,Li, Qian,Yu, Zhi-Xiang. "Rh(I)-catalyzed [5 + 1] cycloaddition of vinylcyclopropanes and CO for the synthesis of α,β- and β,γ-cyclohexenones". supporting information; experimental part. p. 692 - 695. Retrieved 2012/03/26.