3-[1-(4-chloro-benzyl)-3-methyl-5-trifluoromethanesulfonyloxy-1H-indol-2-yl]-2,2-dimethyl-propionic acid methyl ester

Base Information

• Chemical Name: 3-[1-(4-chloro-benzyl)-3-methyl-5-trifluoromethanesulfonyloxy-1H-indol-2-yl]-2,2-dimethyl-propionic acid methyl ester
• CAS No.: 862555-21-3
• Molecular Formula: C₂₃H₂₃ClF₃NO₅S
• Molecular Weight: 517.954

Synonyms:3-[1-(4-chloro-benzyl)-3-methyl-5-trifluoromethanesulfonyloxy-1H-indol-2-yl]-2,2-dimethyl-propionic acid methyl ester

Chemical Property of 3-[1-(4-chloro-benzyl)-3-methyl-5-trifluoromethanesulfonyloxy-1H-indol-2-yl]-2,2-dimethyl-propionic acid methyl ester

Chemical Property:

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Technology Process of 3-[1-(4-chloro-benzyl)-3-methyl-5-trifluoromethanesulfonyloxy-1H-indol-2-yl]-2,2-dimethyl-propionic acid methyl ester

There total 6 articles about 3-[1-(4-chloro-benzyl)-3-methyl-5-trifluoromethanesulfonyloxy-1H-indol-2-yl]-2,2-dimethyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methyl 3-[1-(4-chlorobenzyl)-3-methyl-5-hydroxyindol-2-yl]-2,2-dimethylpropanoate (148693-70-3) + trifluoromethylsulfonic anhydride (358-23-6) → 3-[1-(4-chloro-benzyl)-3-methyl-5-trifluoromethanesulfonyloxy-1H-indol-2-yl]-2,2-dimethyl-propionic acid methyl ester (862555-21-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃;

DOI:10.1016/j.bmcl.2005.05.027

Reference yield:

3-[1-(4-chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid (103253-35-6) → 3-[1-(4-chloro-benzyl)-3-methyl-5-trifluoromethanesulfonyloxy-1H-indol-2-yl]-2,2-dimethyl-propionic acid methyl ester (862555-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / BBr₃ / CH₂Cl₂ / -60 - 0 °C

2: 81 percent / Et₃N / CH₂Cl₂ / 0 °C

With boron tribromide; triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2005.05.027

Reference yield:

2,2-dimethyl-4-oxohexanoic acid (15118-53-3) → 3-[1-(4-chloro-benzyl)-3-methyl-5-trifluoromethanesulfonyloxy-1H-indol-2-yl]-2,2-dimethyl-propionic acid methyl ester (862555-21-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / 2-methyl-propan-2-ol / 15 h / Heating

2: 100 percent / BBr₃ / CH₂Cl₂ / -60 - 0 °C

3: 81 percent / Et₃N / CH₂Cl₂ / 0 °C

With boron tribromide; triethylamine; In dichloromethane; tert-butyl alcohol; 1: Fisher indole coupling;

DOI:10.1016/j.bmcl.2005.05.027

upstream raw materials:

methyl 3-[1-(4-chlorobenzyl)-3-methyl-5-hydroxyindol-2-yl]-2,2-dimethylpropanoate

trifluoromethylsulfonic anhydride

3-[1-(4-chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid

2,2-dimethyl-4-oxohexanoic acid

Downstream raw materials:

3-[1-(4-chloro-benzyl)-5-(2-fluoro-biphenyl-4-yl)-3-methyl-1H-indol-2-yl]-2,2-dimethyl-propionic acid methyl ester

3-[1-(4-chloro-benzyl)-5-(2-fluoro-2'-methyl-biphenyl-4-yl)-3-methyl-1H-indol-2-yl]-2,2-dimethyl-propionic acid methyl ester

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