N-[4-chloro-5-(1,2-dimethyl-1H-imidazol-4-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide

Base Information

Chemical Name:N-[4-chloro-5-(1,2-dimethyl-1H-imidazol-4-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide
CAS No.:1126368-35-1
Molecular Formula:C₂₅H₂₃ClN₄O₂
Molecular Weight:446.936
Hs Code.:

Synonyms:N-[4-chloro-5-(1,2-dimethyl-1H-imidazol-4-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide

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Chemical Property of N-[4-chloro-5-(1,2-dimethyl-1H-imidazol-4-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide

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Technology Process of N-[4-chloro-5-(1,2-dimethyl-1H-imidazol-4-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide

There total 9 articles about N-[4-chloro-5-(1,2-dimethyl-1H-imidazol-4-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1126367-36-9
N-(4-chloro-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-(pyridin-2-ylmethoxy)benzamide

: 1126368-35-1
N-[4-chloro-5-(1,2-dimethyl-1H-imidazol-4-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; In 1,4-dioxane; water; at 130 ℃; for 2h; Microwave irradiation;
DOI:10.1016/j.bmc.2019.115227

Reference yield:

: 1126367-88-1
5-bromo-4-chloro-2-methylaniline

: 1126368-35-1
N-[4-chloro-5-(1,2-dimethyl-1H-imidazol-4-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; triethylamine / dichloromethane / 2 h / 50 °C

2: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 5 h / 115 °C / Microwave irradiation

3: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 130 °C / Microwave irradiation

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; triethylamine; In 1,4-dioxane; dichloromethane; water; 2: |Suzuki Coupling / 3: |Suzuki Coupling;
DOI:10.1016/j.bmc.2019.115227

Reference yield:

: 6959-47-3
2-chloromethylpyridine hydrochloride

: 1126368-35-1
N-[4-chloro-5-(1,2-dimethyl-1H-imidazol-4-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl acetamide

2: sodium hydroxide / ethanol

3: thionyl chloride / 1 h / 18 - 30 °C

4: pyridine; triethylamine / dichloromethane / 2 h / 50 °C

5: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 5 h / 115 °C / Microwave irradiation

6: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 130 °C / Microwave irradiation

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; potassium acetate; potassium carbonate; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; water; 5: |Suzuki Coupling / 6: |Suzuki Coupling;
DOI:10.1016/j.bmc.2019.115227