1-tert-butyl 4-ethyl 2-(2-benzyloxycarbonylamino-3-ethylpentanoyl)-3-methylsuccinate

Base Information

• Chemical Name: 1-tert-butyl 4-ethyl 2-(2-benzyloxycarbonylamino-3-ethylpentanoyl)-3-methylsuccinate
• CAS No.: 1357010-68-4
• Molecular Formula: C₂₆H₃₉NO₇
• Molecular Weight: 477.598
• Mol file: 1357010-68-4.mol

Synonyms:1-tert-butyl 4-ethyl 2-(2-benzyloxycarbonylamino-3-ethylpentanoyl)-3-methylsuccinate

Chemical Property of 1-tert-butyl 4-ethyl 2-(2-benzyloxycarbonylamino-3-ethylpentanoyl)-3-methylsuccinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-tert-butyl 4-ethyl 2-(2-benzyloxycarbonylamino-3-ethylpentanoyl)-3-methylsuccinate

There total 5 articles about 1-tert-butyl 4-ethyl 2-(2-benzyloxycarbonylamino-3-ethylpentanoyl)-3-methylsuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-benzyloxycarbonylamino-5-ethyl-3-oxoheptanoate (1357010-67-3) + rac-2-(Trifluormethylsulfonyloxy)propionsaeure-ethylester (77902-90-0) → 1-tert-butyl 4-ethyl 2-(2-benzyloxycarbonylamino-3-ethylpentanoyl)-3-methylsuccinate (1357010-68-4)

Guidance literature:

tert-butyl 4-benzyloxycarbonylamino-5-ethyl-3-oxoheptanoate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.166667h;

rac-2-(Trifluormethylsulfonyloxy)propionsaeure-ethylester; In tetrahydrofuran; dichloromethane; mineral oil; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2011.11.015

Reference yield:

2-Ethylbutyraldehyde (97-96-1) → 1-tert-butyl 4-ethyl 2-(2-benzyloxycarbonylamino-3-ethylpentanoyl)-3-methylsuccinate (1357010-68-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydrogensulfite / methanol; water / 12 h / 60 °C

2.1: hydrogen bromide / 2 h / 150 °C

3.1: sodium hydroxide / 17 h / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

4.2: 1.5 h / -78 - 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

5.2: 2 h / 20 °C

With hydrogen bromide; sodium hydride; sodium hydrogensulfite; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water; mineral oil;

DOI:10.1016/j.bmc.2011.11.015

Reference yield:

2-amino-3-ethylpentanoic acid hydrobromide (1357011-04-1) → 1-tert-butyl 4-ethyl 2-(2-benzyloxycarbonylamino-3-ethylpentanoyl)-3-methylsuccinate (1357010-68-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / 17 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: 1.5 h / -78 - 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

3.2: 2 h / 20 °C

With sodium hydride; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; mineral oil;

DOI:10.1016/j.bmc.2011.11.015

upstream raw materials:

2-Ethylbutyraldehyde

2-amino-3-ethylpentanoic acid hydrobromide

2-benzyloxycarbonylamino-3-ethylpentanoic acid

tert-butyl 4-benzyloxycarbonylamino-5-ethyl-3-oxoheptanoate

Downstream raw materials:

ethyl 5-benzyloxycarbonylamino-6-ethyl-2-methyl-4-oxo-octanoate

benzyl [2-ethyl-1-(5-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)butyl]carbamate

5-(1-ethylpropyl)-2-(4-methoxy-2-methylphenyl)-3,7-dimethylimidazo[1,5-b]pyridazine

Refernces