2-Aza-bicyclo[2.1.1]hexane-1-carboxylic acid benzyl ester; compound with toluene-4-sulfonic acid

Base Information

• Chemical Name: 2-Aza-bicyclo[2.1.1]hexane-1-carboxylic acid benzyl ester; compound with toluene-4-sulfonic acid
• CAS No.: 103794-05-4
• Molecular Formula: C₇H₈O₃S*C₁₃H₁₅NO₂
• Molecular Weight: 389.472
• Mol file: 103794-05-4.mol

Synonyms:2-Aza-bicyclo[2.1.1]hexane-1-carboxylic acid benzyl ester; compound with toluene-4-sulfonic acid

Chemical Property of 2-Aza-bicyclo[2.1.1]hexane-1-carboxylic acid benzyl ester; compound with toluene-4-sulfonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Aza-bicyclo[2.1.1]hexane-1-carboxylic acid benzyl ester; compound with toluene-4-sulfonic acid

There total 1 articles about 2-Aza-bicyclo[2.1.1]hexane-1-carboxylic acid benzyl ester; compound with toluene-4-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-azabicyclo[2.1.1]hexane-1-carboxylic acid (73550-56-8) + toluene-4-sulfonic acid (104-15-4) + benzyl alcohol (100-51-6,185532-71-2) → 2-Aza-bicyclo[2.1.1]hexane-1-carboxylic acid benzyl ester; compound with toluene-4-sulfonic acid (103794-05-4)

Guidance literature:

In benzene; for 16h; Heating;

DOI:10.1021/ja00281a051

Reference yield: 96.0%

2-Aza-bicyclo[2.1.1]hexane-1-carboxylic acid benzyl ester; compound with toluene-4-sulfonic acid (103794-05-4) + methylamine (74-89-5) → 2,4-MePro-NHMe (103794-07-6)

Guidance literature:

In water; for 3h; Heating;

DOI:10.1021/ja00281a051

Reference yield:

2-Aza-bicyclo[2.1.1]hexane-1-carboxylic acid benzyl ester; compound with toluene-4-sulfonic acid (103794-05-4) → L-Tyr-2,4-MePro-NHMe (103794-09-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / H₂O / 3 h / Heating

2: 70 percent / DCC / dimethylformamide / 3 h / Ambient temperature

3: 30percent trifluoroacetic acid / CH₂Cl₂ / 3 h / Ambient temperature

With dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ja00281a051

upstream raw materials:

2-azabicyclo[2.1.1]hexane-1-carboxylic acid

toluene-4-sulfonic acid

benzyl alcohol

Downstream raw materials:

2-Acetyl-2-aza-bicyclo[2.1.1]hexane-1-carboxylic acid benzyl ester

2,4-MePro-NHMe

L-Tyr-2,4-MePro-NHMe

Ac-L-Tyr-2,4-MePro-NHMe