1,4-trans-1-(((tert-butyldiphenylsilyl)oxy)methyl)-4-(methoxymethoxy)cyclohexa-2,5-dienecarboxylic acid

Base Information

Chemical Name:1,4-trans-1-(((tert-butyldiphenylsilyl)oxy)methyl)-4-(methoxymethoxy)cyclohexa-2,5-dienecarboxylic acid
CAS No.:1410840-56-0
Molecular Formula:C₂₆H₃₂O₅Si
Molecular Weight:452.623
Hs Code.:

Synonyms:1,4-trans-1-(((tert-butyldiphenylsilyl)oxy)methyl)-4-(methoxymethoxy)cyclohexa-2,5-dienecarboxylic acid

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Chemical Property of 1,4-trans-1-(((tert-butyldiphenylsilyl)oxy)methyl)-4-(methoxymethoxy)cyclohexa-2,5-dienecarboxylic acid

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Technology Process of 1,4-trans-1-(((tert-butyldiphenylsilyl)oxy)methyl)-4-(methoxymethoxy)cyclohexa-2,5-dienecarboxylic acid

There total 4 articles about 1,4-trans-1-(((tert-butyldiphenylsilyl)oxy)methyl)-4-(methoxymethoxy)cyclohexa-2,5-dienecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₄O₅Si

: 1410840-56-0
1,4-trans-1-(((tert-butyldiphenylsilyl)oxy)methyl)-4-(methoxymethoxy)cyclohexa-2,5-dienecarboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; at 20 - 50 ℃; for 12h;
DOI:10.1021/ol302908a

Reference yield:

: 1410840-49-1
methyl-1-(((tert-butyldiphenylsilyl)oxy)methyl)-4-oxocyclohexa-2,5-dienecarboxylate

: 1410840-56-0
1,4-trans-1-(((tert-butyldiphenylsilyl)oxy)methyl)-4-(methoxymethoxy)cyclohexa-2,5-dienecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: cerium(III) chloride heptahydrate; sodium tetrahydroborate / methanol / 0.33 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

3: lithium hydroxide / tetrahydrofuran; methanol / 12 h / 20 - 50 °C

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol302908a

Reference yield:

: 1410840-47-9
methyl 1-(((tert-butyldiphenylsilyl)oxy)methyl)cyclohexa-2,5-dienecarboxylate

: 1410840-56-0
1,4-trans-1-(((tert-butyldiphenylsilyl)oxy)methyl)-4-(methoxymethoxy)cyclohexa-2,5-dienecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert.-butylhydroperoxide / ethyl acetate; decane / 0.5 h / 20 °C / Molecular sieve

1.2: 48 h / 20 °C

1.3: 0.5 h / 20 °C

2.1: cerium(III) chloride heptahydrate; sodium tetrahydroborate / methanol / 0.33 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

4.1: lithium hydroxide / tetrahydrofuran; methanol / 12 h / 20 - 50 °C

With tert.-butylhydroperoxide; sodium tetrahydroborate; cerium(III) chloride heptahydrate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; decane; dichloromethane; ethyl acetate;
DOI:10.1021/ol302908a