3-Chloro-6-fluoro-2-(1-{5-[1-(trans-4-hydroxycyclohexyl)-5-methyl-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}ethyl)-phenol

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Chemical Name:3-Chloro-6-fluoro-2-(1-{5-[1-(trans-4-hydroxycyclohexyl)-5-methyl-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}ethyl)-phenol
CAS No.:1350325-34-6
Molecular Formula:C₂₅H₂₆ClFN₄O₂
Molecular Weight:468.958
Hs Code.:

Synonyms:3-Chloro-6-fluoro-2-(1-{5-[1-(trans-4-hydroxycyclohexyl)-5-methyl-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}ethyl)-phenol

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Chemical Property of 3-Chloro-6-fluoro-2-(1-{5-[1-(trans-4-hydroxycyclohexyl)-5-methyl-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}ethyl)-phenol

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Technology Process of 3-Chloro-6-fluoro-2-(1-{5-[1-(trans-4-hydroxycyclohexyl)-5-methyl-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}ethyl)-phenol

There total 8 articles about 3-Chloro-6-fluoro-2-(1-{5-[1-(trans-4-hydroxycyclohexyl)-5-methyl-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}ethyl)-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₄₈ClFN₄O₄Si

: 1350325-34-6
3-Chloro-6-fluoro-2-(1-{5-[1-(trans-4-hydroxycyclohexyl)-5-methyl-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}ethyl)-phenol

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 40 ℃; for 2h;

Reference yield:

: 1257997-18-4
1-(trans-4-{[tert-Butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-1H-pyrazole

: 1350325-34-6
3-Chloro-6-fluoro-2-(1-{5-[1-(trans-4-hydroxycyclohexyl)-5-methyl-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}ethyl)-phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / cyclohexane; tetrahydrofuran / 0.08 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 20 °C

2.2: 1 h / 20 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 100 °C / microwave irradiation

4.1: hydrogenchloride; water / 1,4-dioxane / 2 h / 40 °C

With hydrogenchloride; water; isopropylmagnesium chloride; potassium carbonate; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; cyclohexane; water;

Reference yield:

: 1227611-92-8
4-(4-iodo-1H-pyrazol-1-yl)cyclohexanol

: 1350325-34-6
3-Chloro-6-fluoro-2-(1-{5-[1-(trans-4-hydroxycyclohexyl)-5-methyl-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl}ethyl)-phenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; 1H-imidazole / dichloromethane / 0.33 h / 20 °C

2.1: lithium diisopropyl amide / cyclohexane; tetrahydrofuran / 0.08 h / -78 °C

2.2: 0.5 h / -78 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 20 °C

3.2: 1 h / 20 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 100 °C / microwave irradiation

5.1: hydrogenchloride; water / 1,4-dioxane / 2 h / 40 °C

With 1H-imidazole; hydrogenchloride; dmap; water; isopropylmagnesium chloride; potassium carbonate; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water;