1-(trans-4-{[tert-Butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-1H-pyrazole

Base Information

• Chemical Name: 1-(trans-4-{[tert-Butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-1H-pyrazole
• CAS No.: 1257997-18-4
• Molecular Formula: C₁₅H₂₇IN₂OSi
• Molecular Weight: 406.382
• Mol file: 1257997-18-4.mol

Synonyms:1-(trans-4-{[tert-Butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-1H-pyrazole

Chemical Property of 1-(trans-4-{[tert-Butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-1H-pyrazole

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

1-[trans-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclohexyl]-4-iodo-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(trans-4-{[tert-Butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-1H-pyrazole

There total 4 articles about 1-(trans-4-{[tert-Butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(4-iodo-1H-pyrazol-1-yl)cyclohexanol (1227611-92-8) + tert-butyldimethylsilyl chloride (18162-48-6) → 1-(trans-4-{[tert-Butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-1H-pyrazole (1257997-18-4)

Guidance literature:

With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 0.333333h;

Reference yield:

toluene-4-sulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester (23511-05-9) → 1-(trans-4-{[tert-Butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-1H-pyrazole (1257997-18-4)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 100 °C

2: water; pyridinium p-toluenesulfonate / acetone / 16 h / 65 °C

3: ethanol; sodium tetrahydroborate / 2 h / 20 °C / Inert atmosphere

4: dmap; 1H-imidazole / dichloromethane / 0.33 h / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; ethanol; water; pyridinium p-toluenesulfonate; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

4-(4-iodo-1H-pyrazol-1-yl)cyclohexanone (1227611-94-0) → 1-(trans-4-{[tert-Butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-1H-pyrazole (1257997-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; sodium tetrahydroborate / 2 h / 20 °C / Inert atmosphere

2: dmap; 1H-imidazole / dichloromethane / 0.33 h / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; ethanol; In dichloromethane;

upstream raw materials:

4-(4-iodo-1H-pyrazol-1-yl)cyclohexanol

tert-butyldimethylsilyl chloride

toluene-4-sulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester

4-iodo-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazole

Downstream raw materials:

1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-5-(d3)methyl-1H-pyrazole

1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-4-iodo-5-methyl-1H-pyrazole

trans-4-[4-(3-{(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

trans-4-[4-(3-{(1R)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol