4,6-Dimethyl-2-(4-methylphenyl)pyrimidine

Base Information

Chemical Name:4,6-Dimethyl-2-(4-methylphenyl)pyrimidine
CAS No.:97513-48-9
Molecular Formula:C₁₃H₁₄N₂
Molecular Weight:198.268
Hs Code.:
DSSTox Substance ID:DTXSID90558388
Wikidata:Q82440671
Mol file:97513-48-9.mol

Synonyms:4,6-DIMETHYL-2-(4-METHYLPHENYL)PYRIMIDINE;97513-48-9;SCHEMBL11169691;DTXSID90558388;AKOS006306193

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Chemical Property of 4,6-Dimethyl-2-(4-methylphenyl)pyrimidine

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:198.115698455
Heavy Atom Count:15
Complexity:187

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=NC(=CC(=N2)C)C

Technology Process of 4,6-Dimethyl-2-(4-methylphenyl)pyrimidine

There total 5 articles about 4,6-Dimethyl-2-(4-methylphenyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 90252-89-4
p-tolylzinc(II) chloride

: 22325-27-5,131321-42-1
4,6-dimethyl-2-meraptopyrimidine

: 97513-48-9
4,6-dimethyl-2-(p-tolyl)pyrimidine

Guidance literature:: 4,6-dimethyl-2-meraptopyrimidine; With methylzinc chloride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

p-tolylzinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere; Schlenk technique;

In toluene; at 120 ℃; for 24h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.7b03145

Reference yield: 14.0%

: C₂₁H₂₁LiZn

: 22325-27-5,131321-42-1
4,6-dimethyl-2-meraptopyrimidine

: 97513-48-9
4,6-dimethyl-2-(p-tolyl)pyrimidine

Guidance literature:: 4,6-dimethyl-2-meraptopyrimidine; With methylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

C₂₁H₂₁LiZn; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere; Schlenk technique;

In toluene; at 120 ℃; for 24h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.7b03145

Reference yield:

: 106-38-7
para-bromotoluene

: 97513-48-9
4,6-dimethyl-2-(p-tolyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / tetrahydrofuran / 20 °C / Inert atmosphere; Schlenk technique

1.2: 4 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: methylzinc chloride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere; Schlenk technique

2.2: 0.17 h / 20 °C / Inert atmosphere; Schlenk technique

2.3: 24 h / 120 °C / Inert atmosphere; Schlenk technique

With magnesium; methylzinc chloride; In tetrahydrofuran;
DOI:10.1021/acs.orglett.7b03145