3-amino-2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methylbenzamide

Base Information

Chemical Name:3-amino-2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methylbenzamide
CAS No.:1301189-86-5
Molecular Formula:C₁₇H₂₄N₄O₂
Molecular Weight:316.403
Hs Code.:

Synonyms:3-amino-2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methylbenzamide

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Chemical Property of 3-amino-2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methylbenzamide

Chemical Property:

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Technology Process of 3-amino-2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methylbenzamide

There total 8 articles about 3-amino-2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1301189-84-3
2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methyl-3-nitrobenzamide

: 1301189-86-5
3-amino-2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methylbenzamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃;

Reference yield:

: 199175-10-5
1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidinecarboxylate

: 1301189-86-5
3-amino-2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 90 °C

2.1: hydrogenchloride / methanol / 4 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

3.2: 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 132945-76-7
tert-butyl (3R)-3-cyano-1-pyrrolidinecarboxylate

: 1301189-86-5
3-amino-2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / ethanol; water / 3102.97 Torr

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 90 °C

3.1: hydrogenchloride / methanol / 4 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

4.2: 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;