2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methyl-3-nitrobenzamide

Base Information

Chemical Name:2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methyl-3-nitrobenzamide
CAS No.:1301189-84-3
Molecular Formula:C₁₇H₂₂N₄O₄
Molecular Weight:346.386
Hs Code.:

Synonyms:2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methyl-3-nitrobenzamide

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Chemical Property of 2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methyl-3-nitrobenzamide

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Technology Process of 2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methyl-3-nitrobenzamide

There total 7 articles about 2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methyl-3-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₈N₄O₃*(x)ClH

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1301189-84-3
2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methyl-3-nitrobenzamide

Guidance literature:: C₁₃H₁₈N₄O₃*(x)ClH; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

cyclopropanecarboxylic acid chloride; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 317-46-4
2-fluoro-3-nitro-benzoic acid

: 1301189-84-3
2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methyl-3-nitrobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / Reflux

2.1: triethylamine / dichloromethane / 0.5 h / 20 °C

2.2: 0.5 h / -78 °C

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 90 °C

4.1: hydrogenchloride / methanol / 4 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

5.2: 20 °C

With hydrogenchloride; thionyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 199175-10-5
1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidinecarboxylate

: 1301189-84-3
2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-N-methyl-3-nitrobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 90 °C

2.1: hydrogenchloride / methanol / 4 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

3.2: 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; dimethyl sulfoxide;