2-chloro-1-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-ethanone

Base Information

Chemical Name:2-chloro-1-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-ethanone
CAS No.:868408-06-4
Molecular Formula:C₁₅H₁₈ClFN₂O₂
Molecular Weight:312.772
Hs Code.:

Synonyms:2-chloro-1-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-ethanone

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Chemical Property of 2-chloro-1-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-ethanone

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Technology Process of 2-chloro-1-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-ethanone

There total 7 articles about 2-chloro-1-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 864448-43-1
7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]nonane

: 79-04-9
chloroacetyl chloride

: 868408-06-4
2-chloro-1-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-ethanone

Guidance literature:: 7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]nonane; chloroacetyl chloride; In dichloromethane; at 20 ℃; for 0.0833333h;

With sodium carbonate; In dichloromethane; water;

Reference yield:

: 864448-25-9
(S)-ethyl 2-bromo-3-(N-((R)-2-bromo-3-ethoxy-3-oxopropyl)phenyl-sulfonamido)propanoate

: 868408-06-4
2-chloro-1-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-ethanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 1.5 h / 90 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / Heating / reflux

3.1: thionyl chloride / DMF (N,N-dimethyl-formamide); toluene / 1.25 h / 20 - 170 °C / Heating / reflux

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene; xylene / 2 h / Heating / reflux

5.1: tert-butyl methyl ether / 0.17 h / 20 °C

5.2: 2 h / 760.05 Torr

6.1: hydrogenchloride; ethanol; water / 0.5 h

6.2: 1.5 h / Heating / reflux

7.1: dichloromethane / 0.08 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; ethanol; water; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane; tert-butyl methyl ether; toluene; xylene;

Reference yield:

: 864448-27-1
cis-(1-benzyl-4-(phenylsulfonyl)piperazine-2,6-diyl)dimethanol

: 868408-06-4
2-chloro-1-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / DMF (N,N-dimethyl-formamide); toluene / 1.25 h / 20 - 170 °C / Heating / reflux

2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene; xylene / 2 h / Heating / reflux

3.1: tert-butyl methyl ether / 0.17 h / 20 °C

3.2: 2 h / 760.05 Torr

4.1: hydrogenchloride; ethanol; water / 0.5 h

4.2: 1.5 h / Heating / reflux

5.1: dichloromethane / 0.08 h / 20 °C

With hydrogenchloride; thionyl chloride; ethanol; water; sodium bis(2-methoxyethoxy)aluminium dihydride; In DMF (N,N-dimethyl-formamide); dichloromethane; tert-butyl methyl ether; toluene; xylene;