N-(5-chloro-2-{2-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-2-oxoethoxy}-phenyl)acetamide

Base Information

Chemical Name:N-(5-chloro-2-{2-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-2-oxoethoxy}-phenyl)acetamide
CAS No.:868408-04-2
Molecular Formula:C₂₃H₂₅ClFN₃O₄
Molecular Weight:461.921
Hs Code.:

Synonyms:N-(5-chloro-2-{2-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-2-oxoethoxy}-phenyl)acetamide

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Chemical Property of N-(5-chloro-2-{2-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-2-oxoethoxy}-phenyl)acetamide

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Technology Process of N-(5-chloro-2-{2-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-2-oxoethoxy}-phenyl)acetamide

There total 8 articles about N-(5-chloro-2-{2-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-2-oxoethoxy}-phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 868408-06-4
2-chloro-1-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-ethanone

: 26488-93-7
N-(5-chloro-2-hydroxyphenyl)acetamide

: 868408-04-2
N-(5-chloro-2-{2-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-2-oxoethoxy}-phenyl)acetamide

Guidance literature:: N-(5-chloro-2-hydroxyphenyl)acetamide; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 20 ℃; for 0.166667h;

2-chloro-1-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-ethanone; In tetrahydrofuran; toluene; for 1h; Heating / reflux;

Reference yield:

: 864448-25-9
(S)-ethyl 2-bromo-3-(N-((R)-2-bromo-3-ethoxy-3-oxopropyl)phenyl-sulfonamido)propanoate

: 868408-04-2
N-(5-chloro-2-{2-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-2-oxoethoxy}-phenyl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene / 1.5 h / 90 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / Heating / reflux

3.1: thionyl chloride / DMF (N,N-dimethyl-formamide); toluene / 1.25 h / 20 - 170 °C / Heating / reflux

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene; xylene / 2 h / Heating / reflux

5.1: tert-butyl methyl ether / 0.17 h / 20 °C

5.2: 2 h / 760.05 Torr

6.1: hydrogenchloride; ethanol; water / 0.5 h

6.2: 1.5 h / Heating / reflux

7.1: dichloromethane / 0.08 h / 20 °C

8.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.17 h / 20 °C

8.2: 1 h / Heating / reflux

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; ethanol; water; potassium hexamethylsilazane; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane; tert-butyl methyl ether; toluene; xylene;

Reference yield:

: 864448-27-1
cis-(1-benzyl-4-(phenylsulfonyl)piperazine-2,6-diyl)dimethanol

: 868408-04-2
N-(5-chloro-2-{2-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-2-oxoethoxy}-phenyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / DMF (N,N-dimethyl-formamide); toluene / 1.25 h / 20 - 170 °C / Heating / reflux

2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene; xylene / 2 h / Heating / reflux

3.1: tert-butyl methyl ether / 0.17 h / 20 °C

3.2: 2 h / 760.05 Torr

4.1: hydrogenchloride; ethanol; water / 0.5 h

4.2: 1.5 h / Heating / reflux

5.1: dichloromethane / 0.08 h / 20 °C

6.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.17 h / 20 °C

6.2: 1 h / Heating / reflux

With hydrogenchloride; thionyl chloride; ethanol; water; potassium hexamethylsilazane; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane; tert-butyl methyl ether; toluene; xylene;