5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridine

Base Information

Chemical Name:5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridine
CAS No.:1020658-44-9
Molecular Formula:C₂₃H₂₈BF₃N₂O₃
Molecular Weight:448.293
Hs Code.:

Synonyms:5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridine

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Chemical Property of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridine

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridine

There total 1 articles about 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1020658-43-8
5-bromo-2-(4-{[2-(trifluoromethyl)phenyl]}-1-piperidinyl)pyridine

: 73183-34-3
bis(pinacol)diborane

: 1020658-44-9
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridine

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 80 ℃; for 18h;

Reference yield:

: 20986-40-7
ethyl 5-bromo-3-pyridinecarboxylate

: 1020658-44-9
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridine

: 1020658-10-9
ethyl 6'-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-3,3'-bipyridine-5-carboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 4h;

Reference yield:

: 1020658-44-9
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridine

: 118650-08-1
(5-bromo-pyridin-3-yl)-acetic acid methyl ester

: 1020658-27-8
(6'-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-3,3'-bipyridin-5-yl)acetic acid

Guidance literature:: 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridine; (5-bromo-pyridin-3-yl)-acetic acid methyl ester; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 100 ℃;

With water; ammonium chloride;