118650-08-1

Basic information

• Product Name: 3-Pyridineacetic acid, 5-broMo-, Methyl ester
• Synonyms: 3-Pyridineacetic acid, 5-broMo-, Methyl ester
• CAS NO: 118650-08-1
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.05862
• Mol File: 118650-08-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 284.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.517±0.06 g/cm3(Predicted)
• PKA: 2.08±0.21(Predicted)
• CAS DataBase Reference: 3-Pyridineacetic acid, 5-broMo-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridineacetic acid, 5-broMo-, Methyl ester(118650-08-1)
• EPA Substance Registry System: 3-Pyridineacetic acid, 5-broMo-, Methyl ester(118650-08-1)

Safety Data

• Hazardous Substances Data: 118650-08-1(Hazardous Substances Data)

Usage

General Description

3-Pyridineacetic acid, 5-bromo-, Methyl ester is a chemical compound that is derived from pyridine and acetic acid. Its chemical structure includes a 5-bromo substitution and a methyl ester functional group. 3-Pyridineacetic acid, 5-broMo-, Methyl ester may be used in organic synthesis and chemical research as a building block or intermediate. Its properties and potential uses may vary depending on the specific application and context in which it is used. Due to its complex chemical nature, it should be handled and stored with the appropriate safety precautions and regulatory considerations in mind.

Upstream product

• 625-92-3 3,5-dibromopyridine 
• 38330-80-2 monomethyl monopotassium malonate 
• 39891-12-8 5-bromo-3-pyridineacetic acid 
• 74-89-5 methylamine 
• 54648-79-2 N,N’-diisopropyl-O-methylisourea 
• 186581-53-3 diazomethane 
• 67-56-1 methanol 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 597584-53-7 methyl (5-phenylpyridin-3-yl)acetate 
• 936371-69-6 methyl 2-(5-bromopyridin-3-yl)-3-(furan-2-yl)-3-oxopropanoate 
• 1255871-41-0 methyl 1-(5-bromopyridin-3-yl)cyclopropanecarboxylate 
• 1256570-47-4 {3-(hydroxymethyl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone 
• 1256570-49-6 {3-(Azidomethyl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone 
• 1256570-50-9 {3-(aminomethyl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone 
• 1256570-43-0 methyl {5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate 
• 1256569-92-2 cis-N-({1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}methyl)methanesulphonamide 
• 1256569-91-1 cis-N-({1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}methyl)methanesulphonamide 

Relevant articles and documents

A Modular Synthesis of Teraryl-Based α-Helix Mimetics, Part 5: A Complete Set of Pyridine Boronic Acid Pinacol Esters Featuring Side Chains of Proteinogenic Amino Acids

Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein-protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics using pyridine containing boronic acid building blocks to increase the water solubility. Following our initial publication in which we have introduced the methodology in combination with sequential Pd-catalyzed cross-coupling for teraryl assembly, we can now report a complete set of pyridine based boronic acid building blocks decorated with side chains of all proteinogenic amino acids relevant for PPI (Ala, Arg, Asn, Asp, Cys, Gln, Glu, His, Ile, Leu, Lys, Met, Phe, Ser, Thr, Trp, Tyr, Val) to complement the core fragment set. For a representative set of teraryls we have studied the influence of the pyridine rings on the solubility of the assembled oligoarenes.

Mild Esterification of Carboxylic Acids via Continuous Flow Diazotization of Amines

A new continuous flow protocol for the diazotization of methylamine with 1,3-propanedinitrite in THF is reported. The synthesis of methyl esters was achieved in high yields from a variety of carboxylic acids in 20 min at 90 °C. Additionally, this protocol was extended to other aryl and alkyl amines, namely secondary amines, to produce various substituted esters in high yield using 2-MeTHF as a solvent. The reaction conditions were compatible with many functional groups, namely nitrogen-containing heterocycles, alkynes, alkenes, alcohols, and phenols. Mechanistic investigations reveal that the reaction appears to proceed through a transient diazonium species rather than a diazo intermediate.

NEW BICYCLIC DIHYDROISOQUINOLINE-1-ONE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4? R5, R6, A1, A2, A3, A4, A5 and n are as described herein,compositions including the compounds and methods of using the compounds as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrom.