3-Pyridineacetic acid, 5-broMo-, Methyl ester

Base Information

• Chemical Name: 3-Pyridineacetic acid, 5-broMo-, Methyl ester
• CAS No.: 118650-08-1
• Molecular Formula: C8H8BrNO2
• Molecular Weight: 230.061
• Hs Code.: 2933399090
• Mol file: 118650-08-1.mol

Synonyms:3-Pyridineacetic acid, 5-broMo-, Methyl ester

Chemical Property of 3-Pyridineacetic acid, 5-broMo-, Methyl ester

Chemical Property:

• Boiling Point: 284.3±25.0 °C(Predicted)
• PKA: 2.08±0.21(Predicted)
• PSA: 39.19000
• Density: 1.517±0.06 g/cm3(Predicted)
• LogP: 1.55960

Purity/Quality:

97% ^*data from raw suppliers

methyl2-(5-bromopyridin-3-yl)acetate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridineacetic acid, 5-broMo-, Methyl ester

There total 6 articles about 3-Pyridineacetic acid, 5-broMo-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-bromo-3-pyridineacetic acid (39891-12-8) + methylamine (74-89-5) → (5-bromo-pyridin-3-yl)-acetic acid methyl ester (118650-08-1)

Guidance literature:

With propane-1,3-diyl dinitrite; In tetrahydrofuran; at 90 ℃; for 0.333333h; under 12929 Torr; Flow reactor;

DOI:10.1021/acs.orglett.7b02231

Reference yield: 91.0%

methanol (67-56-1) + 5-bromo-3-pyridineacetic acid (39891-12-8) → (5-bromo-pyridin-3-yl)-acetic acid methyl ester (118650-08-1)

Guidance literature:

With thionyl chloride;

DOI:10.1021/jm061425k

Reference yield: 72.0%

5-bromo-3-pyridineacetic acid (39891-12-8) + diazomethyl-trimethyl-silane (18107-18-1) → (5-bromo-pyridin-3-yl)-acetic acid methyl ester (118650-08-1)

Guidance literature:

In methanol; diethyl ether; toluene; at 20 ℃; for 0.166667h;

upstream raw materials:

5-bromo-3-pyridineacetic acid

diazomethyl-trimethyl-silane

methanol

diazomethane

Downstream raw materials:

methyl 2-(5-bromopyridin-3-yl)-3-(furan-2-yl)-3-oxopropanoate

(6'-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-3,3'-bipyridin-5-yl)acetic acid

(5-{2-[(N-tert-butoxycarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid methyl ester

{3-(hydroxymethyl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone

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