(S)-ethyl 2-(benzyloxycarbonylamino)-5-((S)-1-ethoxy-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoate

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Chemical Name:(S)-ethyl 2-(benzyloxycarbonylamino)-5-((S)-1-ethoxy-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoate
CAS No.:1064033-40-4
Molecular Formula:C₂₀H₂₈N₂O₈
Molecular Weight:424.451
Hs Code.:

Synonyms:(S)-ethyl 2-(benzyloxycarbonylamino)-5-((S)-1-ethoxy-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoate

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Chemical Property of (S)-ethyl 2-(benzyloxycarbonylamino)-5-((S)-1-ethoxy-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoate

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Technology Process of (S)-ethyl 2-(benzyloxycarbonylamino)-5-((S)-1-ethoxy-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoate

There total 5 articles about (S)-ethyl 2-(benzyloxycarbonylamino)-5-((S)-1-ethoxy-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 4117-31-1
ethyl L-serinate

: 5672-81-1
(4S)-4-{[(benzyloxy)carbonyl]amino}-5-ethoxy-5-oxopentanoic acid

: 1064033-40-4
(S)-ethyl 2-(benzyloxycarbonylamino)-5-((S)-1-ethoxy-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoate

Guidance literature:: (4S)-4-{[(benzyloxy)carbonyl]amino}-5-ethoxy-5-oxopentanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 1.5h; Inert atmosphere;

ethyl L-serinate; In acetonitrile; at 20 ℃; for 16h;

Reference yield:

: 56-85-9,26700-71-0
L-glutamine

: 1064033-40-4
(S)-ethyl 2-(benzyloxycarbonylamino)-5-((S)-1-ethoxy-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / toluene; water / 20 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 97 h / Inert atmosphere

3.1: tert.-butylnitrite / acetonitrile / 2 h / Inert atmosphere; Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

4.2: 16 h / 20 °C

With tert.-butylnitrite; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 2650-64-8
Cbz-L-Gln

: 1064033-40-4
(S)-ethyl 2-(benzyloxycarbonylamino)-5-((S)-1-ethoxy-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 97 h / Inert atmosphere

2.1: tert.-butylnitrite / acetonitrile / 2 h / Inert atmosphere; Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

3.2: 16 h / 20 °C

With tert.-butylnitrite; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; acetonitrile;