5672-81-1

Upstream product

• 4668-41-1 N₂-benzyloxycarbonyl-l-glutamine ethyl ester 
• 241161-72-8 ethyl N-benzyloxycarbonyl-L-2-amino-5-hexenoate 
• 80963-13-9 Z-Glu(OBzl)-OCH₂CH₃ 
• 23632-67-9 (S)-3-[3-(benzyloxycarbonyl)-5-oxooxazolidin-4-yl]propanoic acid 
• 141-52-6 sodium ethanolate 
• 64942-50-3 2-amino-pentanedioic acid 1-ethyl ester; hydrochloride 
• 501-53-1 benzyl chloroformate 
• 141-78-6 ethyl acetate 
• 1245613-21-1 (S)-2-benzyloxycarbonylaminopentanedioic acid 1-ethyl ester 5-propyl ester 
• 1245613-18-6 (S)-2-benzyloxycarbonylaminopentanedioic acid 1-ethyl ester 5-(2-methoxyethyl) ester 
• 927810-89-7 (S)-2-benzyloxycarbonylaminopentanedioic acid 1-ethyl ester 5-allyl ester 
• 1155-62-0 N-benzyloxycarbonyl-L-glutamic acid 
• 3886-08-6 5-tert-butyl N-benzyloxycarbonyl-L-glutamate 
• 927810-92-2 1-ethyl 5-(2,2,2-trichloroethyl) (S)-2-(benzyloxycarbonylamino)pentanedioate 

Downstream Products

• 883451-77-2 N-(O-ethyl-N-benzyloxycarbonyl-L-γ-glutamyl)-L-glutamic acid diethyl ester 
• 57471-68-8 2-benzyloxycarbonylamino-pentanedioic acid diethyl ester 
• 927810-89-7 (S)-2-benzyloxycarbonylaminopentanedioic acid 1-ethyl ester 5-allyl ester 
• 1064033-40-4 (S)-ethyl 2-(benzyloxycarbonylamino)-5-((S)-1-ethoxy-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoate 
• 6398-06-7 N-benzyloxycarbonyl-L-isoglutamine 
• 5707-87-9 N-benzyloxycarbonyl-L-glutamic acid-1-hydrazide 
• 52454-78-1 L-glutamic acid α-ethyl ester 
• 84563-47-3 glorin 
• 1116-22-9 γ-L-glutamyl-L-glutamic acid 
• 15401-16-8 N-[S-benzyl-N-(N-benzyloxycarbonyl-L-γ-glutamyl)-L-cysteinyl]-glycine 
• 244121-81-1 C₅₇H₇₂N₂O₂₁ 
• 244121-84-4 (S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-carboxymethyl ester 1-ethyl ester 
• 16450-41-2 L-glutamic acid diethyl ester 
• 927810-92-2 1-ethyl 5-(2,2,2-trichloroethyl) (S)-2-(benzyloxycarbonylamino)pentanedioate 

Relevant academic research and scientific papers

PRODUCTION PROCESSES OF S- AND O-DIACYLATED GAMMA-GLUTAMYL-CYSTEAMINE PRODRUGS

Methods are provided for the synthesis of a compound of formula (X). R2 is selected from -H, -C1-C4-alkyl,-C2-C4-alkenyl and C1-C4-aryl; R3 is selected from -C(O)H and

Versatile synthesis of the signaling peptide glorin

We present a versatile synthesis of the eukaryotic signaling peptide glorin as well as glorinamide, a synthetic analog. The ability of these compounds to activate glorin-induced genes in the social amoeba Polysphondylium pallidum was evaluated by quantita

Synthesis and physicochemical characterization of the impurities of pemetrexed disodium, an anticancer drug

A physicochemical characterization of the process-related impurities associated with the synthesis of pemetrexed disodium was performed. The possibility of pemetrexed impurities forming has been mentioned in literature, but no study on their structure has been published yet. This paper describes the development of the synthesis methods for these compounds and discusses their structure elucidation on the basis of two-dimensional NMR experiments and MS data. The identification of these impurities should be useful for the quality control during the production of the pemetrexed disodium salt.

Bacillus subtilis esterase (BS2) and its double mutant have different selectivity in the removal of carboxyl protecting groups

An esterase from Bacillus subtilis (BS2) and its double mutant E188W/M193C quickly hydrolyze n-butyl, n-propyl, methoxyethyl and allyl esters. The wild-type BS2 preferentially removes such esters from the y-position of glutamate diesters, while the engineered enzyme has a reversed selectivity removing esters from the a-position of glutamate diesters. Automated docking and molecular dynamic simulations were performed to understand the molecular reason for the different regioselectivity.

COMPOSITIONS AND METHODS FOR PROTECTING CELLS FROM TOXIC EXPOSURES

The present invention provides compositions and methods for protecting cells and tissues from damage associated with therapeutic treatments of cancers and other diseases and conditions where reactive oxygen species are produced. The present invention also

Enzymatic removal of carboxyl protecting groups. III. Fast removal of allyl and chloroethyl esters by Bacillus subtilis esterase (BS2)

(Chemical Equation Presented) An esterase from Bacillus subtilis (BS2) allows the fast and selective removal of allyl, 2-chloroethyl, and 2,2,2-chloroethyl esters under mild conditions in high yields. In addition, BS2 easily hydrolyzes phenacyl esters, while the hydrolysis of sterically hindered diphenylmethyl esters is slow, requiring longer reaction time and higher enzyme/substrate ratio.

A simple modular synthesis of pyridinoline a collagen cross-link of biochemical interest

A simple convergent synthesis of the collagen cross-link pyridinoline starting from glycine is reported.

Pyridyl-containing spirocyclic compounds as inhibitors of fibrinogen-dependent platelet aggregation

Disclosed are certain substituted or unsubstituted pyridyl-containing spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibiting platelet aggregation, inhibiting the binding of fibrinogen to blood platelets, and preventing or treating thrombosis

Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: Design of potent and specific 3,9-diazaspiro[5.5]undecanes

The synthesis and biological activity of novel glycoprotein IIb-IIIa antagonists containing the 3,9-diazaspiro[5.5]undecane nucleus are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spirocyclic structures as a central template for nonpeptide RGD mimics.

The chemistry of phosphapeptides: Investigations on the synthesis of phosphonamidate, phosphonate, and phosphinate analogues of glutamyl-γ-glutamate

The synthesis of the phosphonamidate, 1d, and phosphonate, 1e, analogues of a γ-glutamyl peptide are reported. Michaelis-Albuzov reaction with the alkyl halide, 7b, derived from L-glutamic acid, yielded dimethyl phosphonate, 8b. Selective aminolysis of th