α,α-Bis(4-fluorophenyl)-1-(3-phenoxypropyl)-4-piperidinemethanol oxalate

Base Information

Chemical Name:α,α-Bis(4-fluorophenyl)-1-(3-phenoxypropyl)-4-piperidinemethanol oxalate
CAS No.:111625-85-5
Molecular Formula:C₂H₂O₄*C₂₇H₂₉F₂NO₂
Molecular Weight:527.565
Hs Code.:

Synonyms:α,α-Bis(4-fluorophenyl)-1-(3-phenoxypropyl)-4-piperidinemethanol oxalate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α,α-Bis(4-fluorophenyl)-1-(3-phenoxypropyl)-4-piperidinemethanol oxalate

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Technology Process of α,α-Bis(4-fluorophenyl)-1-(3-phenoxypropyl)-4-piperidinemethanol oxalate

There total 5 articles about α,α-Bis(4-fluorophenyl)-1-(3-phenoxypropyl)-4-piperidinemethanol oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 3384-04-1
3-chloropropyl phenyl ether

: 144-62-7,97993-78-7
oxalic acid

: 60284-98-2
1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

: 111625-85-5
α,α-Bis(4-fluorophenyl)-1-(3-phenoxypropyl)-4-piperidinemethanol oxalate

Guidance literature:: With sodium carbonate; potassium iodide; 1) n-butanol, reflux;
DOI:10.1021/jm00121a022

Reference yield:

: ethyl N-(3-phenoxypropyl)isonipecotate

: 460-00-4
1-Bromo-4-fluorobenzene

: 111625-85-5
α,α-Bis(4-fluorophenyl)-1-(3-phenoxypropyl)-4-piperidinemethanol oxalate

Guidance literature:: With ammonium chloride; iodine; oxalic acid; magnesium; In tetrahydrofuran; methanol; drytetrahydrofuran;

Reference yield:

: 24228-40-8
N-benzyl isonipecotic acid ethyl ester

: 111625-85-5
α,α-Bis(4-fluorophenyl)-1-(3-phenoxypropyl)-4-piperidinemethanol oxalate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 66 percent / 1) Na₂CO₃, KI / 1) n-butanol, reflux

With hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00121a022