2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyronitrile

Base Information

• Chemical Name: 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyronitrile
• CAS No.: 323197-77-9
• Molecular Formula: C₂₂H₂₃NO₆
• Molecular Weight: 397.428
• Mol file: 323197-77-9.mol

Synonyms:2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyronitrile

Chemical Property of 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyronitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyronitrile

There total 2 articles about 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(benzo[d][1,3]dioxol-6-yl)ethanone (3162-29-6) → 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyronitrile (323197-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / NaOH / ethanol; H₂O / 20 °C

2: 84 percent / AcOH / H₂O; various solvent(s) / 1.23 h / 115 °C

With sodium hydroxide; acetic acid; In ethanol; water;

DOI:10.1021/jo0012849

Reference yield:

4,5-dimethoxy-2-isopropoxybenzene-1-carboaldehyde (96501-85-8) → 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyronitrile (323197-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / NaOH / ethanol; H₂O / 20 °C

2: 84 percent / AcOH / H₂O; various solvent(s) / 1.23 h / 115 °C

With sodium hydroxide; acetic acid; In ethanol; water;

DOI:10.1021/jo0012849

Reference yield: 90.0%

2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyronitrile (323197-77-9) → 2-(2-isopropoxy-4,5-dimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyric acid (323197-78-0)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 90 - 96 ℃; for 3.5h;

DOI:10.1021/jo0012849

upstream raw materials:

1-(benzo[d][1,3]dioxol-6-yl)ethanone

4,5-dimethoxy-2-isopropoxybenzene-1-carboaldehyde

Downstream raw materials:

2-(2-isopropoxy-4,5-dimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyric acid

2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)butyric acid

3,4-dihydro-2-(4,5-dimethoxy-2-isopropoxyphenyl)-6,7-methylenedioxy-1(2H)-naphthalenone

2-(4,5-dimethoxy-2-hydroxyphenyl)-6,7-methylenedioxy-1-(N-methylformamido)naphthalene