2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)butyric acid

Base Information

• Chemical Name: 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)butyric acid
• CAS No.: 323197-79-1
• Molecular Formula: C₂₂H₂₆O₇
• Molecular Weight: 402.444
• Mol file: 323197-79-1.mol

Synonyms:2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)butyric acid

Chemical Property of 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)butyric acid

There total 5 articles about 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-(2-isopropoxy-4,5-dimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyric acid (323197-78-0) → 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)butyric acid (323197-79-1)

Guidance literature:

With hydrogen; pyrographite; palladium dichloride; In acetic acid; for 25h;

DOI:10.1021/jo0012849

Reference yield:

4,5-dimethoxy-2-isopropoxy-3',4'-methylenedioxychalcone (323197-76-8) → 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)butyric acid (323197-79-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / AcOH / H₂O; various solvent(s) / 1.23 h / 115 °C

2: 90 percent / NaOH / ethanol; H₂O / 3.5 h / 90 - 96 °C

3: 81 percent / H₂ / PdCl₂; Norit / acetic acid / 25 h

With sodium hydroxide; hydrogen; acetic acid; pyrographite; palladium dichloride; In ethanol; water; acetic acid;

DOI:10.1021/jo0012849

Reference yield:

2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyronitrile (323197-77-9) → 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)butyric acid (323197-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / NaOH / ethanol; H₂O / 3.5 h / 90 - 96 °C

2: 81 percent / H₂ / PdCl₂; Norit / acetic acid / 25 h

With sodium hydroxide; hydrogen; pyrographite; palladium dichloride; In ethanol; water; acetic acid;

DOI:10.1021/jo0012849

upstream raw materials:

2-(2-isopropoxy-4,5-dimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyric acid

4,5-dimethoxy-2-isopropoxy-3',4'-methylenedioxychalcone

2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyronitrile

1-(benzo[d][1,3]dioxol-6-yl)ethanone

Downstream raw materials:

3,4-dihydro-2-(4,5-dimethoxy-2-isopropoxyphenyl)-6,7-methylenedioxy-1(2H)-naphthalenone

2-(4,5-dimethoxy-2-hydroxyphenyl)-6,7-methylenedioxy-1-(N-methylformamido)naphthalene

2-(4,5-dimethoxy-2-isopropoxyphenyl)-6,7-methylenedioxy-1-(N-methylformamido)naphthalene