3,4-dihydro-2-(4,5-dimethoxy-2-isopropoxyphenyl)-6,7-methylenedioxy-1(2H)-naphthalenone

Base Information

Chemical Name:3,4-dihydro-2-(4,5-dimethoxy-2-isopropoxyphenyl)-6,7-methylenedioxy-1(2H)-naphthalenone
CAS No.:323197-80-4
Molecular Formula:C₂₂H₂₄O₆
Molecular Weight:384.429
Hs Code.:

Synonyms:3,4-dihydro-2-(4,5-dimethoxy-2-isopropoxyphenyl)-6,7-methylenedioxy-1(2H)-naphthalenone

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Chemical Property of 3,4-dihydro-2-(4,5-dimethoxy-2-isopropoxyphenyl)-6,7-methylenedioxy-1(2H)-naphthalenone

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Technology Process of 3,4-dihydro-2-(4,5-dimethoxy-2-isopropoxyphenyl)-6,7-methylenedioxy-1(2H)-naphthalenone

There total 6 articles about 3,4-dihydro-2-(4,5-dimethoxy-2-isopropoxyphenyl)-6,7-methylenedioxy-1(2H)-naphthalenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 323197-79-1
2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)butyric acid

: 323197-80-4
3,4-dihydro-2-(4,5-dimethoxy-2-isopropoxyphenyl)-6,7-methylenedioxy-1(2H)-naphthalenone

Guidance literature:: 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)butyric acid; With thionyl chloride; for 1h; cooling;

With tin(IV) chloride; In chloroform; at -63 - -60 ℃; for 1.08333h; Further stages.;
DOI:10.1021/jo0012849

Reference yield:

: 323197-76-8
4,5-dimethoxy-2-isopropoxy-3',4'-methylenedioxychalcone

: 323197-80-4
3,4-dihydro-2-(4,5-dimethoxy-2-isopropoxyphenyl)-6,7-methylenedioxy-1(2H)-naphthalenone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 84 percent / AcOH / H₂O; various solvent(s) / 1.23 h / 115 °C

2.1: 90 percent / NaOH / ethanol; H₂O / 3.5 h / 90 - 96 °C

3.1: 81 percent / H₂ / PdCl₂; Norit / acetic acid / 25 h

4.1: SOCl₂ / 1 h / cooling

4.2: 91 percent / SnCl₄ / CHCl₃ / 1.08 h / -63 - -60 °C

With sodium hydroxide; thionyl chloride; hydrogen; acetic acid; pyrographite; palladium dichloride; In ethanol; water; acetic acid;
DOI:10.1021/jo0012849

Reference yield:

: 323197-77-9
2-(4,5-dimethoxy-2-isopropoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxobutyronitrile

: 323197-80-4
3,4-dihydro-2-(4,5-dimethoxy-2-isopropoxyphenyl)-6,7-methylenedioxy-1(2H)-naphthalenone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / NaOH / ethanol; H₂O / 3.5 h / 90 - 96 °C

2.1: 81 percent / H₂ / PdCl₂; Norit / acetic acid / 25 h

3.1: SOCl₂ / 1 h / cooling

3.2: 91 percent / SnCl₄ / CHCl₃ / 1.08 h / -63 - -60 °C

With sodium hydroxide; thionyl chloride; hydrogen; pyrographite; palladium dichloride; In ethanol; water; acetic acid;
DOI:10.1021/jo0012849