2,4-Di-tert-butyl-6-phenol

Base Information

• Chemical Name: 2,4-Di-tert-butyl-6-phenol
• CAS No.: 128203-38-3
• Molecular Formula: C₁₆H₂₇NO
• Molecular Weight: 249.396
• Mol file: 128203-38-3.mol

Synonyms:2,4-Di-tert-butyl-6-phenol

Chemical Property of 2,4-Di-tert-butyl-6-phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-Di-tert-butyl-6-phenol

There total 2 articles about 2,4-Di-tert-butyl-6-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2,4-di-tert-Butylphenol (96-76-4) + methylamine (74-89-5) → 2,4-Di-tert-butyl-6-phenol (128203-38-3)

Guidance literature:

In 1,4-dioxane; for 48h; Ambient temperature; 35percent aq. Methylamine;

DOI:10.1016/S0040-4020(01)81363-6

Reference yield:

2,4-di-tert-butyl-6-(1,1-dimethylaminomethyl)phenol (32857-07-1) → 2,4-Di-tert-butyl-6-phenol (128203-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 7 percent / O₂ / FeCl₂/Fe⁰ / methanol; H₂O / 48 h / 70 °C / 4560 Torr

2: 65 percent / dioxane / 48 h / Ambient temperature; 35percent aq. Methylamine

With oxygen; iron; iron(II) chloride; In 1,4-dioxane; methanol; water;

DOI:10.1016/S0040-4020(01)81363-6

Reference yield: 29.0%

2,4-Di-tert-butyl-6-phenol (128203-38-3) → Methylimino-2,2'-dimethylene-bis-(4,6-di-tert-butyl-phenol) (120695-70-7)

Guidance literature:

With oxygen; In methanol; at 70 ℃; for 96h; under 760 Torr;

DOI:10.1016/S0040-4020(01)81363-6

upstream raw materials:

formaldehyd

2,4-di-tert-Butylphenol

methylamine

2,4-di-tert-butyl-6-(1,1-dimethylaminomethyl)phenol

Downstream raw materials:

3,5-di-tert-butyl-2-hydroxybenzaldehyde

N-methyl-2,3-dihydro-1H-6,8-bis(1,1-dimethylethyl)benz[1,2-e][1,3]oxazine

Methylimino-2,2'-dimethylene-bis-(4,6-di-tert-butyl-phenol)

Refernces