(E)-2-(diphenylmethyleneamino)-N-methoxy-N-methyl-7-{1-[2-methyl-3-(naphthalen-1-yl)allyl]-1H-1,2,3-triazol-4-yl}heptanamide

Base Information

Chemical Name:(E)-2-(diphenylmethyleneamino)-N-methoxy-N-methyl-7-{1-[2-methyl-3-(naphthalen-1-yl)allyl]-1H-1,2,3-triazol-4-yl}heptanamide
CAS No.:1353046-58-8
Molecular Formula:C₃₈H₄₁N₅O₂
Molecular Weight:599.776
Hs Code.:

Synonyms:(E)-2-(diphenylmethyleneamino)-N-methoxy-N-methyl-7-{1-[2-methyl-3-(naphthalen-1-yl)allyl]-1H-1,2,3-triazol-4-yl}heptanamide

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Chemical Property of (E)-2-(diphenylmethyleneamino)-N-methoxy-N-methyl-7-{1-[2-methyl-3-(naphthalen-1-yl)allyl]-1H-1,2,3-triazol-4-yl}heptanamide

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Technology Process of (E)-2-(diphenylmethyleneamino)-N-methoxy-N-methyl-7-{1-[2-methyl-3-(naphthalen-1-yl)allyl]-1H-1,2,3-triazol-4-yl}heptanamide

There total 4 articles about (E)-2-(diphenylmethyleneamino)-N-methoxy-N-methyl-7-{1-[2-methyl-3-(naphthalen-1-yl)allyl]-1H-1,2,3-triazol-4-yl}heptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1353046-56-6
(E)-ethyl 2-(diphenylmethyleneamino)-7-[1-(2-methyl-3-(naphthalen-1-yl)allyl)-1H-1,2,3-triazol-4-yl]heptanoate

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1353046-58-8
(E)-2-(diphenylmethyleneamino)-N-methoxy-N-methyl-7-{1-[2-methyl-3-(naphthalen-1-yl)allyl]-1H-1,2,3-triazol-4-yl}heptanamide

Guidance literature:: With isopropylmagnesium chloride; In tetrahydrofuran; at -20 - 0 ℃; for 2h; Inert atmosphere;
DOI:10.1002/cmdc.201100316

Reference yield:

: 1353046-54-4
(E)-ethyl 7-[1-(3-bromo-2-methylallyl)-1H-1,2,3-triazol-4-yl]-2-(diphenylmethyleneamino)heptanoate

: 1353046-58-8
(E)-2-(diphenylmethyleneamino)-N-methoxy-N-methyl-7-{1-[2-methyl-3-(naphthalen-1-yl)allyl]-1H-1,2,3-triazol-4-yl}heptanamide

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 20 h / 69 °C

2: isopropylmagnesium chloride / tetrahydrofuran / 2 h / -20 - 0 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; isopropylmagnesium chloride; sodium carbonate; In tetrahydrofuran; water;
DOI:10.1002/cmdc.201100316

Reference yield:

: 69555-14-2
ethyl N-diphenylmethylene glycine

: 1353046-58-8
(E)-2-(diphenylmethyleneamino)-N-methoxy-N-methyl-7-{1-[2-methyl-3-(naphthalen-1-yl)allyl]-1H-1,2,3-triazol-4-yl}heptanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

1.2: 69 h / 0 - 20 °C

2.1: copper(II) sulfate; sodium L-ascorbate / dichloromethane; water; tert-butyl alcohol / 12 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 20 h / 69 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / -20 - 0 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium tert-butylate; isopropylmagnesium chloride; sodium carbonate; copper(II) sulfate; sodium L-ascorbate; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/cmdc.201100316