(R)-1-methyl-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine

Base Information

Chemical Name:(R)-1-methyl-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine
CAS No.:952490-88-9
Molecular Formula:C₁₃H₁₅F₃N₂O₃
Molecular Weight:304.269
Hs Code.:

Synonyms:(R)-1-methyl-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine

Suppliers and Price of (R)-1-methyl-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-1-methyl-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-1-methyl-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine

There total 7 articles about (R)-1-methyl-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 952490-85-6
(R)-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 952490-88-9
(R)-1-methyl-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine

Guidance literature:: With sodium cyanoborohydride; In water; acetonitrile; at 20 ℃;
DOI:10.1021/jm070034i

Reference yield:

: 69411-67-2
2-fluoro-4-nitro-1-(trifluoromethyl)benzene

: 34381-71-0
(S)-2-hydroxymethyl-1-methylpyrrolidine

: 952490-88-9
(R)-1-methyl-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 48h;
DOI:10.1016/j.bmcl.2013.01.105

Reference yield:

: 769961-18-4
(R)-2-(5-nitro-2-trifluoromethyl-phenoxymethyl)-1-(tert-butylcarbonyl)pyrrolidine

: 952490-88-9
(R)-1-methyl-2-((5-nitro-2-(trifluoromethyl)phenoxy)methyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂ / 1 h / 20 °C

2: 73 percent / sodium cyanoborohydride / H₂O; acetonitrile / 20 °C

With sodium cyanoborohydride; trifluoroacetic acid; In dichloromethane; water; acetonitrile;
DOI:10.1021/jm070034i