(R)-3-(3-(benzyloxy)-1-(2,5-dichloropyridin-3-ylamino)-1-oxopropan-2-yloxy)-2,6-difluorobenzamide

Base Information

Chemical Name:(R)-3-(3-(benzyloxy)-1-(2,5-dichloropyridin-3-ylamino)-1-oxopropan-2-yloxy)-2,6-difluorobenzamide
CAS No.:1403884-23-0
Molecular Formula:C₂₂H₁₇Cl₂F₂N₃O₄
Molecular Weight:496.297
Hs Code.:

Synonyms:(R)-3-(3-(benzyloxy)-1-(2,5-dichloropyridin-3-ylamino)-1-oxopropan-2-yloxy)-2,6-difluorobenzamide

Suppliers and Price of (R)-3-(3-(benzyloxy)-1-(2,5-dichloropyridin-3-ylamino)-1-oxopropan-2-yloxy)-2,6-difluorobenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-3-(3-(benzyloxy)-1-(2,5-dichloropyridin-3-ylamino)-1-oxopropan-2-yloxy)-2,6-difluorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-3-(3-(benzyloxy)-1-(2,5-dichloropyridin-3-ylamino)-1-oxopropan-2-yloxy)-2,6-difluorobenzamide

There total 6 articles about (R)-3-(3-(benzyloxy)-1-(2,5-dichloropyridin-3-ylamino)-1-oxopropan-2-yloxy)-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78607-32-6
3-amino-2,5-dichloropyridine

: 1403884-22-9
(R)-3-(benzyloxy)-2-(3-carbamoyl-2,4-difluorophenoxy)propanoyl chloride

: 1403884-23-0
(R)-3-(3-(benzyloxy)-1-(2,5-dichloropyridin-3-ylamino)-1-oxopropan-2-yloxy)-2,6-difluorobenzamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

: 23680-31-1
BOC-O-benzyl-L-serine

: 1403884-23-0
(R)-3-(3-(benzyloxy)-1-(2,5-dichloropyridin-3-ylamino)-1-oxopropan-2-yloxy)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / 0.75 h / 20 °C

1.2: 20 h / 5 - 20 °C / pH 4

2.1: sulfuric acid / 16 h / Reflux

3.1: triethylamine; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 48.66 h / 0 - 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

4.2: pH 4

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C / Cooling with ice

6.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

With oxalyl dichloride; sulfuric acid; water; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium hydroxide; diethylazodicarboxylate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 130111-08-9,127744-27-8
(S)-3-(benzyloxy)-2-hydroxypropanoic acid

: 1403884-23-0
(R)-3-(3-(benzyloxy)-1-(2,5-dichloropyridin-3-ylamino)-1-oxopropan-2-yloxy)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 16 h / Reflux

2.1: triethylamine; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 48.66 h / 0 - 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

3.2: pH 4

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C / Cooling with ice

5.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

With oxalyl dichloride; sulfuric acid; water; triethylamine; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;