6-(3-Bromo-5-nitro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole; hydrochloride

Base Information

Chemical Name:6-(3-Bromo-5-nitro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole; hydrochloride
CAS No.:145235-76-3
Molecular Formula:C₁₁H₁₀BrN₃O₂S*ClH
Molecular Weight:364.65
Hs Code.:

Synonyms:6-(3-Bromo-5-nitro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole; hydrochloride

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Chemical Property of 6-(3-Bromo-5-nitro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole; hydrochloride

Chemical Property:

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Technology Process of 6-(3-Bromo-5-nitro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole; hydrochloride

There total 4 articles about 6-(3-Bromo-5-nitro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6307-83-1
3-bromo-5-nitro-benzoic acid

: 145235-76-3
6-(3-Bromo-5-nitro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / dimethylformamide / 3 h / Heating

2: 2.) 48percent HBr / 1.) CHCl₃, ether, from -50 deg C to RT, 2.) CH₂Cl₂, RT, 1 h

3: acetone / 1.) RT, 1 h, 2.) reflux, 0.5 h

4: NaBH₄ / methanol / 1 h / Ambient temperature

5: SOCl₂ / CHCl₃ / 1 h / Heating

6: aq. K₂CO₃ / CHCl₃ / 1 h / Heating

With sodium tetrahydroborate; thionyl chloride; hydrogen bromide; potassium carbonate; In methanol; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0223-5234(92)90184-3

Reference yield:

: 145028-82-6
3-[2-(3-Bromo-5-nitro-phenyl)-2-chloro-ethyl]-thiazolidin-2-ylideneamine

: 145235-76-3
6-(3-Bromo-5-nitro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole; hydrochloride

Guidance literature:: With potassium carbonate; In chloroform; for 1h; Heating;
DOI:10.1016/0223-5234(92)90184-3

Reference yield:

: 145028-77-9
1-(3-Bromo-5-nitro-phenyl)-2-(2-imino-thiazolidin-3-yl)-ethanol

: 145235-76-3
6-(3-Bromo-5-nitro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CHCl₃ / 1 h / Heating

2: aq. K₂CO₃ / CHCl₃ / 1 h / Heating

With thionyl chloride; potassium carbonate; In chloroform;
DOI:10.1016/0223-5234(92)90184-3