3-[4-(chloromethyl)thiazol-2-yl]-1-(cyclohexyl)methyl-7-methoxy-1H-indole

Base Information

Chemical Name:3-[4-(chloromethyl)thiazol-2-yl]-1-(cyclohexyl)methyl-7-methoxy-1H-indole
CAS No.:865712-61-4
Molecular Formula:C₂₀H₂₃ClN₂OS
Molecular Weight:374.934
Hs Code.:

Synonyms:3-[4-(chloromethyl)thiazol-2-yl]-1-(cyclohexyl)methyl-7-methoxy-1H-indole

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Chemical Property of 3-[4-(chloromethyl)thiazol-2-yl]-1-(cyclohexyl)methyl-7-methoxy-1H-indole

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Technology Process of 3-[4-(chloromethyl)thiazol-2-yl]-1-(cyclohexyl)methyl-7-methoxy-1H-indole

There total 1 articles about 3-[4-(chloromethyl)thiazol-2-yl]-1-(cyclohexyl)methyl-7-methoxy-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 865712-60-3
1-(cyclohexyl)methyl-7-methoxy-1H-indole-3-carbothioic acid amide

: 534-07-6
1,3-Dichloroacetone

: 865712-61-4
3-[4-(chloromethyl)thiazol-2-yl]-1-(cyclohexyl)methyl-7-methoxy-1H-indole

Guidance literature:: In toluene; at 40 ℃;
DOI:10.1016/j.bmcl.2010.10.093

Reference yield: 51.0%

: 865712-61-4
3-[4-(chloromethyl)thiazol-2-yl]-1-(cyclohexyl)methyl-7-methoxy-1H-indole

: 109-89-7
diethylamine

: 1266133-66-7
C₂₄H₃₃N₃OS

Guidance literature:: In acetonitrile; at 150 ℃; Microwave irradiation;
DOI:10.1016/j.bmcl.2010.10.093

Reference yield:

: 865712-61-4
3-[4-(chloromethyl)thiazol-2-yl]-1-(cyclohexyl)methyl-7-methoxy-1H-indole

: 38256-93-8
N-methyl-N-(2-methoxyethyl)amine

: 1-(cyclohexyl)methyl-7-methoxy-3-(4-{[N-(2-methoxyethyl)-N-methylamino]methyl}-[1,3]-thiazol-2-yl)-1H-indole hydrochloride

Guidance literature:: 3-[4-(chloromethyl)thiazol-2-yl]-1-(cyclohexyl)methyl-7-methoxy-1H-indole; N-methyl-N-(2-methoxyethyl)amine; In 1,4-dioxane; acetonitrile; at 160 ℃; for 0.166667h; Irradiation;

With sodium hydroxide; In 1,4-dioxane; water; acetonitrile;

With hydrogenchloride; In diethyl ether;