2-Benzyloxymethyl-3-t-butyldimethylsiloxy-1-propanol

Base Information

Chemical Name:2-Benzyloxymethyl-3-t-butyldimethylsiloxy-1-propanol
CAS No.:117087-19-1
Molecular Formula:C₁₇H₃₀O₃Si
Molecular Weight:310.509
Hs Code.:
DSSTox Substance ID:DTXSID301138607

Synonyms:SCHEMBL8719986;OZJYUMCRPONPPS-UHFFFAOYSA-N;DTXSID301138607;2-benzyloxymethyl-3-t-butyldimethylsiloxy-1-propanol;2-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-3-(phenylmethoxy)-1-propanol;117087-19-1

Suppliers and Price of 2-Benzyloxymethyl-3-t-butyldimethylsiloxy-1-propanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Benzyloxymethyl-3-t-butyldimethylsiloxy-1-propanol

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:9
Exact Mass:310.19642135
Heavy Atom Count:21
Complexity:280

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OCC(CO)COCC1=CC=CC=C1

Technology Process of 2-Benzyloxymethyl-3-t-butyldimethylsiloxy-1-propanol

There total 3 articles about 2-Benzyloxymethyl-3-t-butyldimethylsiloxy-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 117087-18-0
2-((benzyloxy)methyl)propane-1,3-diol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 117087-19-1
2-[(benzyloxy)methyl]-3-[(tert-butyldimethylsilyl)oxy]propan-1-ol

Guidance literature:: 2-[(benzyloxy)methyl]propane-1,3-diol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.75h;

tert-butyldimethylsilyl chloride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 117087-17-9
5-[(benzyloxy)methyl]-2,2-dimethyl-1,3-dioxane

: 117087-19-1
2-[(benzyloxy)methyl]-3-[(tert-butyldimethylsilyl)oxy]propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / methanol / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.75 h / 20 °C

2.2: 1 h / 20 °C

With sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol;

Reference yield:

: 100-39-0
benzyl bromide

: 117087-19-1
2-[(benzyloxy)methyl]-3-[(tert-butyldimethylsilyl)oxy]propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 1 h / 20 °C

1.2: 18 h / 20 °C

2.1: toluene-4-sulfonic acid / methanol / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.75 h / 20 °C

3.2: 1 h / 20 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol;