tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)phenoxy)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate

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Chemical Name:tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)phenoxy)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate
CAS No.:1565835-81-5
Molecular Formula:C₄₅H₄₄FN₅O₃
Molecular Weight:721.874
Hs Code.:

Synonyms:tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)phenoxy)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)phenoxy)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)phenoxy)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate

There total 11 articles about tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)phenoxy)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1283167-96-3
4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)phenol

: 1440753-74-1
tert-butyl 4-(2-hydroxy-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate

: 1565835-81-5
tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)phenoxy)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate

Guidance literature:: With tributylphosphine; diamide; In toluene; at 0 - 60 ℃; for 32h;
DOI:10.1021/jm500632s

Reference yield:

: 1440753-63-8
tert-butyl 4-(2-(benzyl(tert-butoxycarbonyl)amino)-2-oxo-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate

: 1565835-81-5
tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)phenoxy)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 15 h / 20 °C

2: tributylphosphine; diamide / toluene / 32 h / 0 - 60 °C

With sodium tetrahydroborate; tributylphosphine; diamide; In tetrahydrofuran; ethanol; toluene; 2: |Mitsunobu Displacement;
DOI:10.1021/jm500632s

Reference yield:

: 1565835-76-8
2-(4-(allyloxy)phenyl)-1-(4-fluorobenzyl)-1H-benzo[d]imidazole

: 1565835-81-5
tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)phenoxy)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / methanol / 20 °C

2: tributylphosphine; diamide / toluene / 32 h / 0 - 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tributylphosphine; diamide; potassium carbonate; In methanol; toluene; 2: |Mitsunobu Displacement;
DOI:10.1021/jm500632s