(5-Chloromethyl-5-methyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-phenyl-amine

Base Information

• Chemical Name: (5-Chloromethyl-5-methyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-phenyl-amine
• CAS No.: 36912-23-9
• Molecular Formula: C₁₁H₁₅ClNO₃P
• Molecular Weight: 275.672

Synonyms:(5-Chloromethyl-5-methyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-phenyl-amine

Chemical Property of (5-Chloromethyl-5-methyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-phenyl-amine

Chemical Property:

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Technology Process of (5-Chloromethyl-5-methyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-phenyl-amine

There total 2 articles about (5-Chloromethyl-5-methyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-phenyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trans-2-chloro-5-methyl-1,3,2-dioxaphosphorinane-r-5-methyl chloride 2-oxide (28097-07-6) + aniline (62-53-3) → (5-Chloromethyl-5-methyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-phenyl-amine (36912-23-9)

Guidance literature:

With triethylamine; In benzene; for 6.5h; Heating;

DOI:10.1055/s-1983-30370

Reference yield:

4-methyl-2,6,7-trioxa-1-phosphabicyclo-[2,2,2]-octane (1449-91-8) → (5-Chloromethyl-5-methyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-phenyl-amine (36912-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SO₂Cl₂ / CCl₄

With sulfuryl dichloride; In tetrachloromethane;

DOI:10.1021/jo00942a014

Reference yield: 10.0%

(5-Chloromethyl-5-methyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-phenyl-amine (36912-23-9) → 4-Methyl-7-phenyl-2,6-dioxa-7-aza-1-phospha-bicyclo[2.2.2]octane 1-oxide (86947-47-9)

Guidance literature:

With sodium hydride; In 1,3,5-trimethyl-benzene; for 9h; Heating;

DOI:10.1055/s-1983-30370

upstream raw materials:

trans-2-chloro-5-methyl-1,3,2-dioxaphosphorinane-r-5-methyl chloride 2-oxide

aniline

4-methyl-2,6,7-trioxa-1-phosphabicyclo-[2,2,2]-octane

Downstream raw materials:

4-Methyl-7-phenyl-2,6-dioxa-7-aza-1-phospha-bicyclo[2.2.2]octane 1-oxide

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