8-oxo-4,8-dihydro-2-phenyl-5-(3'-hydroxypropyl)-4H-pyridino[3,2-d]-m-dioxin

Base Information

Chemical Name:8-oxo-4,8-dihydro-2-phenyl-5-(3'-hydroxypropyl)-4H-pyridino[3,2-d]-m-dioxin
CAS No.:216580-37-9
Molecular Formula:C₁₆H₁₇NO₄
Molecular Weight:287.315
Hs Code.:

Synonyms:8-oxo-4,8-dihydro-2-phenyl-5-(3'-hydroxypropyl)-4H-pyridino[3,2-d]-m-dioxin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-oxo-4,8-dihydro-2-phenyl-5-(3'-hydroxypropyl)-4H-pyridino[3,2-d]-m-dioxin

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Technology Process of 8-oxo-4,8-dihydro-2-phenyl-5-(3'-hydroxypropyl)-4H-pyridino[3,2-d]-m-dioxin

There total 1 articles about 8-oxo-4,8-dihydro-2-phenyl-5-(3'-hydroxypropyl)-4H-pyridino[3,2-d]-m-dioxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.8%

: 156-87-6
propan-1-ol-3-amine

: 216579-21-4
8-oxo-4,8-dihydro-2-phenyl-4H-pyrano[3,2-d]-m-dioxin

: 216580-37-9
8-oxo-4,8-dihydro-2-phenyl-5-(3'-hydroxypropyl)-4H-pyridino[3,2-d]-m-dioxin

Guidance literature:: With sodium hydroxide; In ethanol; for 3h; Heating; pH=12.5;
DOI:10.1021/jm991080o

Reference yield: 89.7%

: 65-85-0,8013-63-6
benzoic acid

: 216580-37-9
8-oxo-4,8-dihydro-2-phenyl-5-(3'-hydroxypropyl)-4H-pyridino[3,2-d]-m-dioxin

: 216580-53-9
8-oxo-4,8-dihydro-2-phenyl-5-[(3'-benzoyloxy)propyl]-4H-pyridino[3,2-d]-m-dioxin

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm991080o

Reference yield:

: 216580-37-9
8-oxo-4,8-dihydro-2-phenyl-5-(3'-hydroxypropyl)-4H-pyridino[3,2-d]-m-dioxin

: 1-[(3'-benzoyloxy)propyl]-2-hydroxymethyl-3-hydroxypyridin-4(1H)-one hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 89.7 percent / Ph₃P; DEAD / tetrahydrofuran / 20 °C

2: 85 percent / aq. HCl; H₂ / 5 percent Pd/C / dimethylformamide / 6 h

With hydrogenchloride; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Esterification / 2: Hydrogenolysis;
DOI:10.1021/jm991080o